Bull and the TAC team struggle to adjust to a virtual court system as they weather the New York City shutdown due to the coronavirus.

The TAC team experiences a conflict of interest in court when Benny represents the plaintiff and Chunk represents the defendant in the same civil suit, where a mother sues a young artist she deems responsible for her daughter's death.

Bull assists Chunk as he represents a convict from his law school’s legal aid clinic, a woman accused of killing a guard while trying to escape during a prison transport. While the prosecution alleges the woman shot the guard as she tried to flee, Chunk argues that she is being falsely accused by a guard who attempted to sexually assault her during the transport.

TAC braces for an un-jolly Christmas when Bull and Benny represent Marissa and her estranged husband, Greg, in federal court after they're charged with money laundering and fraud connected to Greg's restaurant. As Bull and Benny defend the divorcing couple together so the prosecution can't use them against each other, they search for jurors who will believe Marissa had no knowledge of Greg's business dealings. Also, as Bull and Izzy prepare to baptize Astrid before the Christmas holiday, they reach an impasse regarding what they want from their renewed relationship.

Bull worries he can't convince a jury his religious leader client didn't kill his wife when a major secret the pastor is hiding about the marriage is revealed, damaging his credibility in court.

Bull and Chunk represent an emergency room doctor being sued for malpractice after she ignored direct orders to save one near-death patient in favor of helping another who was also critically injured.

Bull and Benny mount a difficult federal trial defense for a young mother accused of aiding and abetting her extremist husband in an act of domestic terrorism. When the controversial case makes news, Benny's commitment to TAC complicates his burgeoning political career.

Bull heads to federal court for a client accused of stealing his own scientific research from the company he works for, a corporation he says buried his ground-breaking work because selling medication is more profitable than curing diseases

Bull uses the First Amendment's freedom of speech to defend a controversial news commentator blamed for a man's suicide after she accused him on air of murder

Izzy asks Bull to petition the court to have her best friend’s body exhumed when the woman’s son alleges she was murdered, despite her death already ruled accidental.

The origin story of TAC is revealed through flashbacks when Bull tries to get a new trial for the wrongly convicted prisoner who inspired him to work in trial science 12 years earlier.

Bull and the TAC team worry about jury bias when Bull mounts a murder trial defense for a Black Lives Matter activist who is also the son of the wrongly convicted man who inspired Bull to start his trial science company.

Bull is hired to help a woman determined to go against legal advice when she insists on pleading guilty to the murder of a wealthy philanthropist who preyed on her a teenager.

Bull aims to win over a federal jury without the use of hard evidence when TAC represents Hank Alston, a child recovery agent charged with fraud for not having documented proof of his covert work. Also, Izzy wants Benny to consider hitting back at his opponent in the District Attorney race when the other candidate engages in mudslinging before an important debate

Izzy puts the brakes on her wedding to Bull after he jeopardizes Benny’s election campaign by handling the defense in the corruption trial of the former District Attorney that Benny hopes to replace. Season finale.