Ellen reflects on some of the toughest and most gratifying moments of her life, and she and Dave make mischief on the set of her talk show.

Tiffany Haddish lights up the stage as she talks Dave through her journey from foster care to the bar mitzvah party circuit to big-time movie roles.

World Champion Formula One driver Lewis Hamilton looks back on his scrappy beginnings and gives Dave the thrill of a lifetime on the racetrack.

Melinda Gates breaks down big global challenges and explains why it's vital to get more women in tech. Dave makes sandwiches with her husband, Bill.

Joining Dave at a special Netflix event, Zach Galifianakis pays tribute to childhood idols and shares juicy tidbits from the "Between Two Ferns" set.