Melissa has tried to cover a huge lipoma with a sweatshirt for years; Tyler's fear of cancer has kept him from having his huge head lumps diagnosed; Tahj is covered in painful boils; Amber has ear keloids that have taken control of her life.

Ronen's mysterious lump above his knee is one of the largest Dr. Lee has ever seen; Amber suffers from a debilitating skin disease that no one understands; Sandy has a neck lump she calls Tommy; Kristy's eyelid cyst is ruining her life.

Half of Mary's body is a size 18 while the other is an 8; Anthony's cyst is in the area called the Triangle of Death; Shane wants to get a lump off his back; Brandi's anxiety may keep her from getting a lump removed from her chest.

Belinda's lump on her neck causes her to basically be immobile; Nicole won't get married until she gets her arm pit lump removed; Adela's chest and back are covered in wisdom spots; Nick foolishly removed a lipoma at home and now needs Dr. Lee's help.

Taylor has a large bump at the base of her spine that is far more dangerous than she realizes. John jokes about hip lump, but turns out it's no laughing matter. Noelle had her ears stretched as a teenager, but now wants them repaired.