While investigating the disappearance of multiple ships in the Sargasso Sea, Dr. Quest discovers a secret laser base (operated by a foreign provocateur and protected by lizard-suited scuba divers) hidden aboard an 18th-century shipwreck.

A foreign submarine crew races Dr. Quest and his recovery team (aboard an American icebreaker) to a downed experimental missile in the Arctic ice cap.

A former archaeologist friend-turned Arab nationalist revolutionary named Ahmed Kareem, who is being stalked by a vengeful mummy, attempts to frame Dr. Quest and Race for the theft of a priceless Egyptian artifact.

While going to the aid of a captive fellow scientist in the Amazon jungle, Dr. Quest is abducted (for ritual sacrifice) by a tribe of hostile native warriors.