Clark and General Lane are both having a hard time giving Lois room to make her own decisions. Meanwhile, Lana and Sarah have a run-in with an old friend at the diner. Lastly, Natalie has a surprise visitor.

Lois and Clark dig deeper on Bruno Mannheim, starting with his connections to Hob's Bay Medical Center, while Jonathan and Jordan panic at home over Lois' dire diagnosis. Meanwhile, Matteo comes to Smallville to meet John Henry for the first time, and Sarah and Chrissy start to break the ice.

In the wake of learning that Bruno and Peia are married, Clark works to reignite Lois' interest in taking Bruno down. Elsewhere, Natalie meets Matteo's parents for the first time, with disastrous consequences. Meanwhile, the Kent boys clash when Jordan interferes with Jonathan's training at the Firehouse, Lana bonds with General Lane over their shared fear of dating again, and Sarah realizes her mom needs a friend.