After a routine one-hour flight from Minneapolis, Northwest Airlink Flight 5719 crashes in northern Minnesota, killing everyone on board. Investigators face intense pressure to find the cause. The cockpit voice recorder raises disturbing questions about an inexperienced pilot. But as investigators dig deeper, they uncover a troubling pattern of abuse that led to a breakdown in human cooperation.

Just minutes after taking off from New York's JFK Airport, TWA Flight 800 is ripped apart by a massive explosion. With a possible terror attack on their hands, the FBI joins investigators from the NTSB in an urgent search for answers. Both agencies are hoping for quick results, but the investigation into TWA Flight 800 will eventually pit them against one another, and will turn into one of the longest, most costly and challenging ever conducted.

On 31 July 1992, Thai Airways International Flight 311 crashes into a mountain while on final approach to Tribhuvan International Airport in Kathmandu, Nepal, in poor weather conditions, killing all 99 passengers and 14 crew members on board.

On 16 February 2000, Emery Worldwide Flight 17 crashes into an automobile salvage yard shortly after taking off from Sacramento Mather Airport on a flight to Dayton, Ohio, killing all 3 crew members on board.

(Trigana Air Flight 267) A turboprop crashes into an Indonesian mountain, and while three systems could have prevented it, investigators must figure out why none of them did.