A massive tornado sweeps through Austin, as Owen, Michelle and their teams race to save those in its path.

The crew race to a rattlesnake infestation, and attempt to rescue a man with dementia from a dangerous scene he created; Michelle learns the truth behind her sister's disappearance; A tragic accident shakes the crew to its core.

The 126 crew responds to a military tank on the loose in downtown Austin and a human pile-up at the roller derby. Meanwhile, new paramedic captain, Tommy Vega, joins the team and Owen is reunited with his ex-wife and T.K.'s mother, Gwyneth, and receives an update on his cancer.

Judd is shocked at the latest victim of an emergency call, Grace and Carlos must save a woman literally trapped in a domestic abuse situation and the 126 arrive at a horrific highway crash that threatens the lives of a father and daughter. Meanwhile, Owen and Gwyneth face a difficult decision in their relationship and Mateo regrets his new tattoo.