Owen Strand, the lone survivor of his Manhattan firehouse on 9/11, takes his progressive philosophies of life and firefighting down to Austin, Texas, where he helps the firefighters of Firehouse 126 start anew.

The crew races to a disaster at a wave pool, and an outbreak of mercury poisoning that is leaving its victims in a a zombie-like state. Meanwhile, Owen must come to terms with his illness and what the side-effects of treatment may do to his vanity. Also, Michelle follows a new lead on her missing sister while TK is unsure how to handle his budding relationship with Carlos.

Judd calls out Owen's preferential treatment of T.K.. Marjan feels ostracized at her new mosque after another rescue video goes viral. Owen helps Michelle uncover new information about her sister's disappearance.

A massive tornado sweeps through Austin, as Owen, Michelle and their teams race to save those in its path.

The crew race to a brawl at a male strip club, a fire at a bull semen factory and a protest where male toxicity is taken to a new level; Grace tries to reconnect with Judd; Owen faces the consequences of his chemo.

Emergencies include a ride-share trip gone awry, a farming accident and a memorial service that may turn into another funeral. Owen unexpectedly bonds with the former Captain of the 126 (guest star Billy Burke), while Marjan and the crew help Mateo try to pass his written exams.

The crew deal with a runaway bull at a used car lot and an apparent electrocution at the hands of an LA transplant; Michelle gets the strongest lead yet on her missing sister.

The crew race to a rattlesnake infestation, and attempt to rescue a man with dementia from a dangerous scene he created; Michelle learns the truth behind her sister's disappearance; A tragic accident shakes the crew to its core.

Owen and the 126 crew race to a gender reveal party gone horribly wrong, and a father/son trapped in a cave during a spelunking excursion. Meanwhile, Owen helps T.K. reconcile the past to help his future, Judd and Grace aid Judd's aging father.

Owen helps T.K. reconcile the past to help his future; Michelle learns the full truth about Iris.

The 126 crew responds to a military tank on the loose in downtown Austin and a human pile-up at the roller derby. Meanwhile, new paramedic captain, Tommy Vega, joins the team and Owen is reunited with his ex-wife and T.K.'s mother, Gwyneth, and receives an update on his cancer.

After a volcanic eruption wreaks havoc in Austin, the members of the 126 race to save lives at a college pool party, a family's mini-golf outing and a woman trapped in her food truck by a horde of scorpions.

As a wildfire spreads across Texas, Evan "Buck" Buckley, Henrietta "Hen" Wilson and Eddie Diaz from the 118 firehouse in Los Angeles arrive in Austin to help Capt. Strand and the 126. As the crews race to save a group of teenagers trapped by the fire at a campground, Owen and Hen fight for their lives in the aftermath of a helicopter crash.