Peter discovers that Mary-Jane is working with a mysterious cult. Baron Mordo, head of the cult, wants them to steal the Wand of Watoom to free his master, Dormammu. And when Mordo manages to get his hands on the wand, Spider-Man must team up with Doctor Strange and his sidekick Wong, to stop them!

Under the psychiatric care of Dr. Kafka, Eddie Brock has come to believe that Venom is a figment of his imagination. Then Baron Mordo tempts Eddie -- reunification with the alien symbote that makes him as powerful as Venom.

Spider-Man and Venom must put aside their differences and help Iron Man stop Carnage and Baron Mordo from releasing Dormammu.