Peter Parker przeprowadza wywiad z naukowcem, Mariah Crawford. Kiedy Peter dociera do jej biura, zostaje zaatakowana przez złoczyńcę, Kravena Łowcę, po tym, gdy Spider-Manowi udaje się mu wymknąć. Dr Crawford wyjaśnia, że Kraven i ona kiedyś byli zakochani, ale kiedy został poważnie poraniony przez lwy, nie miała wyboru i podała mu cudowny lek, który mógł uleczyć wszystkie rany. Przy tym rozwijał jednak zwierzęce zmysły i zdolności, które także zmieniły jego osobowość. Spider-Man podrzuca Mariah do mieszkania Robbiego, myśląc, że jest poza miastem, ale kiedy Robbie wraca wcześniej, Kraven porywa go myśląc, że ten jest partnerem Crawford.

Wolverine catches up with Spider-Man, hot on the trail of the missing Hank McCoy. Discovering his location and the plot to destroy all mutantkind the two team up and rescue Beast in the nick of time just as he was about to become the first test subject of Landon's horrendous plan. But when Landon accidentally falls victim to his own experiment he is changed into a giant monster that feeds on electrical energy. Can Spider-Man and the X-Men succeed in stopping this 50-foot tall, ohm-eating monster?

Dr. Mariah Crawford has developed a cure for Spidey's disease, but she's reluctant to give an untested serum to Spider-Man that may result in permanent loss of his powers or worse. But after an angry outburst from Spider-Man, she hands it over. Peter, at the ESU lab, is secretly observed by Michael Morbius, who then swipes the infected blood sample after Peter leaves for the night. Working alone in the campus bell tower with borrowed equipment, Morbius has an accident which will change him forever...

The Punisher comes to New York to deal with the mutating Spider-Man, who has just grown four extra arms, and is in search for also mutated Morbius who is killing (eating) innocent people, and the people of New York blame Spider-Man for all that is happening.

After Spider-Man mutates into the Man-Spider, Dr. Mariah Crawford summons Sergi Kravenoff, better known as Kraven The Hunter, to help her track down Spider-Man and cure him of his mutation with a newly developed antidote. Unfortunately, the Punisher is hot on Spidey's heels. Will the Punisher succeed in destroying Spider-Man in his new mutated form or will Kraven and Dr. Crawford reach him first?