In 1990, a serial killer terrorizes the University of Florida’s campus, killing 5 students in under 4 days. “The Gainesville Ripper” leaves behind a bizarre crime scene where all the victims have been stabbed but the females have been posed like dolls.

In New Jersey four bodies are found dismembered, bagged, and thrown in roadside garbage cans. The “Last Call Killer" hunted his victims openly in piano bars but no one suspected he could be hiding in plain sight, working as a local nurse.

Dallas police discover three women murdered with their eyes surgically removed; police believe they have a deranged doctor on the loose until two rookie cops find themselves on the trail of a man with a talent for taxidermy and a hatred for women.

A killer hijacks the highways of Sacramento as several women are found strangled with their clothing cut into precise but odd patterns; a survivor leads police to a sports car driving deviant posing as a good samaritan to poach potential victims.

When the Hillside Stranglers are caught police realize they still have another serial killer running rampant in Los Angeles; he tortures and toys with his model victims while keeping pieces of their jewelry as he snaps their last photo ever.

Texas authorities have a killer riding the rails and leaving a literal trail of bread crumbs after eating at victims' tables; when more murders are linked, the FBI names a Most Wanted suspect and a national manhunt for The Railroad Killer ensues.