Puberty syndrome – Abnormal experiences rumored on the internet to be caused by sensitivity and instability during adolescence. This year, Sakuta Azusagawa, a second-year student at a high school near Enoshima, meets several girls that are experiencing this “puberty syndrome.” For instance, he meets a wild bunny girl in the library. She turns out to be an actress on hiatus, Mai Sakurajima, who is also his senior at the school. For some reason, no one else can see this enchanting girl. How did she become invisible…? As Sakuta searches for answers to help Mai, they spend more time together, and he eventually learns of her hidden feelings… This is an unusual story that takes place in a town of bright skies and glistening seas, where Sakuta encounters various intriguing girls.

While looking for the cause of Mai's Adolescence Syndrome, Sakuta ends up scheduling a date with Mai. On the day they promised, Sakuta tries to help out a lost little girl on his way towards Fujisawa Station. But, he is misunderstood to be a perverted maniac by another girl, and because of that, he ends up arriving late to his appointed time to meet Mai. He somehow gains Mai's forgiveness and they proceed with their date, but Mai changes their destination, and takes Sakuta to Shichirigahama Beach...

With Nodoka's Puberty Syndrome resolved, Sakuta's expectations to spend sweeter times with Mai is growing. But then, a scandal is reported by the media about Mai Sakurajima having a new boyfriend. In the press conference for a movie she had a role in, Mai gives a sincere explanation. Seeing that, Kaede decides to set goals for the rest of the year, wanting to do her best for Sakuta's sake as well. One of the goals she writes down is to go back to school...