Dr. Jack Gallagher arrives for his new job as Director of Psychiatric Services at Los Angeles Wharton Memorial Hospital, and gains the trust of a delusional patient using a unique method. Meanwhile, this maverick psychiatrist must also earn the confidence from his new colleagues and conservative boss, hospital administrator Nora Skoff, who is also his ex-lover.

Gallagher treats a female patient who says she is seven months pregnant, yet isn't even pregnant at all. Her husband has also been fooled by her delusions. Elsewhere, Gallagher searches the streets for his mentally ill sister, Becky, who he fears is homeless.

An 8-year-old bipolar boy is admitted to Wharton Memorial following a dangerous incident with a knife. When Jack uncovers the accident was a suicide attempt, Jack tries to get inside the boy's head to learn what is causing his outbursts. Meanwhile, Nora learns her daughter is posting provocative pictures of herself on the Internet.

When movie star Liam McBride is checked into the psych ward, he insists he faked the psychotic episode in order to gain publicity for his upcoming movie. However, Jack believes Liam does in fact have a serious problem and refuses to release him. Meanwhile, Nora and Veronica have a girls' night out and share their romantic pasts with one another.

A patient makes a return when it seems his OCD and Tourette's Syndrome has worsened, causing his wife to push for unproven brain surgery, which makes the team believe the wife may have issues of her own. Meanwhile, Jack becomes infatuated with a neurosurgeon.

The murder of a drug dealer has Jack embroiled in a mystery when the only witness is the victim's autistic teenage daughter. The detectives struggle to get any useful information from the teen, but Jack uses unconventional methods to gather clues from her statement. Meanwhile, Arturo receives a visit from his father, who believes he can settle a real medical case since he plays a doctor on a soap opera.

A factory worker has a few fingers chopped off yet refuses to have surgery to reattach them. Meanwhile, Jack argues with his colleagues over Veronica being assigned his sister Becky's case of schizophrenia.

A man trying to check himself into the psych ward claims to be a werewolf. Meanwhile, Nora has a difficult decision to make, and Jack sees a therapist about his recent problems.