When a NYPD officer is hit by a car in the line of duty, the hospital is turn upside down trying to save her. Meanwhile, Kapoor and Iggy work with a patient struggling with a previous surgery.

The doctors stop at nothing to help their patients, following a shocking realization that prompts a change in the hospital. Meanwhile, Reynolds must make an important decision in his career.

Max implements sweeping changes to hospital sustainability practices. Bloom returns from vacation. Reynolds treats a young patient with deadly heat stroke. Iggy discovers a dangerous situation with a former patient.

When an elder care facilitate shuts down, New Amsterdam is forced to intake many new patients. Max struggles with his decision to head back to London. Reynolds takes his personal frustrations out on his department with near disastrous results. Iggy's work causes him to reflect on his marriage and personal life.

Max and Wilder face a dilemma over approvals for a revolutionary cancer drug as Max learns a secret about his own bout with cancer. Reynolds goes the extra mile to correct a dire medical situation. Iggy tries desperately to help a woman in need, but finds the system is working against him.