When the COVID-19 pandemic hits Seattle, the Station 19 crew leans on each other for support. Andy tries to make sense of her mother’s return, while Sullivan settles into a new routine. And it’s all-hands-on-deck when a group of teenagers unintentionally starts a wild fire.

The team responds to a difficult domestic dispute involving a pregnant woman. Meanwhile, Travis struggles to deal with a family crisis, and Maya and Carina’s relationship continues to grow.

Andy, Sullivan, Dean and Ben are faced with a tough choice while trying to save a couple trapped in their car. Meanwhile, Dean second guesses his legal fight against the Seattle Police Department; Travis’ dad fears he will be outed when his “golfing friend” is exposed to COVID-19; and Carina’s immigration status is called into question.

In the wake of national outcry after the tragic murder of an unarmed Black man, Maya brings in Dr. Diane Lewis to grief counsel the team.

Station 19 and Station 23 each attempt to celebrate Thanksgiving following the fallout from the neighborhood explosion. The firefighters come together to cook, toast to loved ones they have lost, and celebrate the families they have become.

Vic and Jack lean on one another as they process the loss of Dean while Ben and Bailey try to convince Dean’s parents to allow them to raise Pru. Meanwhile at Station 23, Andy’s role temporarily expands and Sullivan subs in. Carina and Maya explore growing their family.