When the team responds to an apartment fire, Captain Pruitt takes a hit, the future of the station’s leadership is in jeopardy and firefighter Andy Herrera is forced to step up. Meanwhile, new recruit Ben Warren is trading in the scalpel for a fresh start as a firefighter, but it hasn’t been easy.

With the absence of Captain Pruitt, Andy and Jack try to navigate how to work together, and a car accident on a rural road puts both the victims and the crew’s lives at risk.

Ben reaches a new milestone as a rookie and, as is tradition, receives something from the crew. Chief Ripley holds final interviews for the role of captain but is interrupted when the team is called to a massive skyscraper fire, causing several lives to hang in the balance.

Lives hang in the balance as the members of Station 19 continue to fight a raging inferno inside a skyscraper. Meanwhile, Pruitt’s health is in grave danger at Grey Sloan; and a seasoned firefighter with a mysterious past arrives at Station 19, leaving everyone to wonder what the future holds.

In the aftermath of the windstorm, Andy and Sullivan’s fates remain unknown while trapped in the overturned aid car. Meanwhile, back at the station, the team confronts Jack about his well-being; and when it’s safe enough to venture out, they search for their fellow firefighters in a race against time.

The members of Station 19 pack their gear and head to Los Angeles, California, to help battle a deadly wildfire raging out of control. While the team works to evacuate residents, they meet Terry, and Ben makes a split-second decision that changes both of their lives.

After a car crashes into Joe’s Bar, Andy and Sullivan lead the team of firefighters as they work to rescue their fellow crewmates Ben and Pruitt, Grey Sloan doctors and interns, and bar patrons before the building comes crumbling down.

The crossover continues on Grey's Anatomy S16E10 Help Me Through the Night (II).

The new Seattle fire chief is introduced to Station 19 and leaves the crew skeptical after his visit. Later, the firefighters are called to a department store fire caused by exploding fireworks, which triggers painful memories from Ben’s past and inspires him to pursue a new endeavor. Maya advocates for herself and her career, while Jack becomes more intertwined with an acquaintance; and Andy and Ryan have a heart-to-heart.

As Ben readies the new Physician Response Team truck for the field, his suspicions about Sullivan and the missing Fentanyl continue to grow. Meanwhile, Jack and Rigo try to look past their differences when they are forced to work together and fight a mysterious gas station fire; Dean and JJ try to work through their differing parenting styles; and Travis meets someone new.

Andy becomes painfully suspicious of the circumstances surrounding her mother’s death and goes to her aunt looking for answers. Meanwhile, the members of the crew work to evacuate a doctor from Pac-North hospital and find themselves in a life-threatening situation; and Sullivan undergoes surgery for his chronic leg pain.

When the COVID-19 pandemic hits Seattle, the Station 19 crew leans on each other for support. Andy tries to make sense of her mother’s return, while Sullivan settles into a new routine. And it’s all-hands-on-deck when a group of teenagers unintentionally starts a wild fire.

The future of Sullivan's career hangs in the balance as his disciplinary hearing gets underway, and Ben, Dr. Richard Webber, Emmett Dixon and former Fire Chief Dixon are called to testify. Meanwhile, the crew investigates an electrical fire at a neglected apartment building that serves as the home and performance space for some of Seattle's most prominent drag queens.

Ben and Dean wrestle with life and death after the Black Fighter’s Coalition banquet.

Maya addresses some unresolved family issues, and the crew takes matters into their own hands when faced with a life-or-death moment on scene. Meanwhile, Andy and Sullivan’s marriage is put to the test.

Through a series of flashbacks, Sullivan and Natasha’s past is revealed. Meanwhile, Ben and Bailey have a discussion with Pru’s grandparents, and the crew responds to a fire at a candy factory.

A simulation fire training goes dangerously wrong. Maya tries to make amends, and Bailey encourages Carina to listen. Meanwhile, Jack’s sister shows up at the station with a friend, an injury and an attitude.

A shoddily assembled structure poses a dangerous challenge for our heroes leaving Ben with a difficult choice to make. Maya and Carina work to get their relationship back on track, while Natasha must decide what – or whom – she wants to prioritize.