As Audrey Bayer puts the finishing touches on her husband Greg’s 60th birthday party – a milestone Greg is loath to celebrate – cracks begin to emerge in their progressive, multiracial family. Ramon, the couple’s Colombian-born son, who’s just starting a relationship with Henry, a barista, is having unexplained, recurring encounters with the numbers “11:11.” Duc, adopted from Vietnam, enjoys the fruits of a lucrative career as a “motivational architect,” but his celibacy troubles Audrey. Liberian-born Ashley, a successful fashion-industry exec, is finding more and more reason to shake up her marriage with her husband, Malcolm. And 17-year-old Kristen, the couple’s youngest child, chafes at her banal life, especially compared to her more exotic siblings. After a troubling incident at the birthday party, Audrey and Greg take Ramon to a therapist, Dr. Farid Shokrani, who has an unlikely and unexplainable connection to the young man.

Ramon and Shokrani explore the possible psychic connection between “11:11” and a photograph in the doctor’s office. Kristen and Ashley run into trouble. Duc gets good news about his self-help manuscript, but his mood is dampened by the publisher’s request. Audrey is enlisted to help break up a politically incorrect new society at school. Disturbed in part by a medical diagnosis, Greg loses his cool in the classroom. Ramon crashes a family meeting.

Ramon goes missing after a disturbing family incident. Audrey clashes with Steve during and after a morning talk show. Ashley and Malcolm weigh the pros and cons of a corporate future. Farid’s guilt drives him to extremes, damaging his family ties. Greg gets enlightenment during a visit with Audrey’s brother Ike. A cataclysmic event shakes the family to its core.