Im Herbst 1937 – nach Abschluss seines Studiums – macht sich der Schotte James Herriot auf den Weg nach Yorkshire. Er hofft, eine Anstellung als Assistent in der Landpraxis des Tierarztes Siegfried Farnon zu bekommen. Farnon, ein skurriler, lebensfroher Junggeselle, will dem eifrigen jungen Mann eine Chance geben. Zunächst jedoch muss James sein Können unter Beweis stellen. Farnon nimmt ihn mit über Land und konfrontiert ihn nicht nur mit dem ‚lieben Vieh‘, sondern auch mit den dickköpfigen Farmern, die dem Anfänger mit Skepsis oder gar Spott begegnen.

Siegfried has a major victory, and his brother Tristan has to deal with pigs in more ways than one. James discovers he has a rival for Helen's affections.

James' temper is fraying fast -- what with two car accidents in the space of a week, an inauspicious meeting with Helen's family and his rival still lurking around Helen like a "big glossy spider".

James and Helen's wedding day has finally arrived, though their honeymoon destination couldn't have been further from the Mediterranean. Finally, Siegfried bestows the best wedding present of all.

Siegfried discovers that a gift given in good faith has brought the deadly foot-and-mouth disease to the dales, and James accidentally hits upon a "sleep cure" for Mrs. Flaxton's poodle.

Mrs. Hall is away visiting a cousin and James agrees to fill in for Stewie Brannon while he's on holidays. Siegfried and Tristan make the best of it but Tristan's culinary skills have not improved over the years. He does make an excellent bangers and mash, for every meal, everyday. James treats a severely injured dog and has a bit of difficulty with the local dialect.

England is at war and the time has come for James and Siegfried to join their military units. Their last day at the practice is a busy one and James is repeatedly called out when he had hopes to spend a last, quiet evening at home with Helen. Siegfried surprises James with a small gift. Mrs. Hall also has a surprise announcement for everyone and Tristan receives shocking news from the Royal College of Veterinary Surgeons.

James returns to Darrowby following his wartime service in the R.A.F. Though little has changed in the Dales in the intervening six years, James finds it difficult to adjust to the peacetime routine and to friends and family who seem like strangers.