The doctors work to save one of their own but disagree over what's best for her. Bell is met with an unexpected response when he voices concerns regarding the nursing shortage that Nic brought to his attention.

Devon and Irving are inundated with patients in the ER. When an A-list celebrity enters the hospital after swallowing a wishbone, Logan Kim assigns a new surgeon to the case in the hopes of garnering extra publicity.

Conrad comes under fire when a former patient files a malpractice lawsuit against him, putting Bell in a difficult position with Red Rock. The doctors perform a risky brain surgery. Mina discovers that Adaku has a dangerous heart condition.

Devon and Conrad face a moral dilemma over a suicidal patient who is in need of a liver transplant.

After being terminated, Conrad has difficulty figuring out his next step and distracts himself by accompanying a patient on a zero-gravity adventure. Cain puts the doctors on a commission-based pay system. Bell's company gets its big break.

Conrad meets with a high-profile soccer player suffering from mysterious symptoms. Nic springs into action when she notices Kyle falling into a deep depression and fears he could be suicidal. Devon butts heads with Irving over patient space.

Cain feels disrespected by Logan Kim when he is left out of a major decision regarding Conrad. The doctors work together to try to save the lives of two big Red Rock donors who were involved in a jet skiing accident.

When Nadine's father comes to town for her birthday, Devon enlists help to ensure that he makes the best first impression. Red Rock decides to cut the entire OBGYN department. Nic cares for a teenage patient whose condition is deteriorating.

Conrad finds himself caught between his duties as a doctor and his loyalty to Kit when he discovers that her son-in-law may be suffering from a serious disease. Devon and Nic make a shocking discovery about a former patient.

Cain recruits Ezra to help keep an emergency situation under wraps. Nic works to come up with a support system for a patient in need of a lung transplant. Kit's son-in-law's condition continues to worsen.

Just when Derek's condition seems to be improving, a severe complication arises, causing Kitt to fear that he may be the latest victim of Cain's cover-up. When Cain's former girlfriend is admitted to the hospital for surgery, the doctors finally get a glimpse into his personal life. Meanwhile, Conrad fills in Marshall on the emergency situation facing the hospital and Mina and The Raptor work on saving the heart of a salsa dancer.

After a long wait, Conrad and Nic prepare for their wedding day with the support of their family and friends. Meanwhile, flashbacks to the early days of the COVID-19 crisis shine a light on the heroism of the doctors and the toll the virus took on everyone at Chastain Memorial.

When Cain’s elective surgery patient returns with complications, Mina and Raptor butt heads over how to handle the situation. Conrad and Devon treat a local Congresswoman who withholds information that could prevent her from receiving proper treatment, causing Devon to open up about his grief. In the wake of losing many colleagues to the virus, Bell worries who would be there for him in a moment of crisis and finds himself mining his own past to find his estranged former stepson, elite plastic surgeon Dr. Jake Wong. Meanwhile, Logan Kim finds himself on the chopping block when the doctors are questioned about his actions during the pandemic.