On his first day as an intern, an idealistic Dr. Devon Pravesh faces the harsh realities of medical care, as third year resident Dr. Conrad Hawkins takes him under his wing and teaches his unconventional ways for treating patients. Meanwhile, Conrad goes head-to-head with Chief of Surgery Dr. Solomon Bell, who uses power and intimidation to cover up his mistakes.

Conrad receives the call he's been waiting for when a heart becomes available for a patient who has been on the transplant list for two years. But when a congressman is admitted to the hospital after a heart attack, he is prioritized and derails Conrad's patient's surgery. Meanwhile, Nic grows suspicious of one of the doctors after a file goes missing, Dr. Bell tries to manipulate Mina and Devon is put to the test when a patient's condition requires a split-second decision.

An old army buddy and fellow surgeon visits Conrad at the hospital. Meanwhile, the team is put to the test when they have to save the life of an uninsured and undocumented patient, while simultaneously battling the hospital's administrators, who fear the patient will cost millions. Also, Dr. Bell experiments with a new medication for his tremor and Nic swears to investigate the mystery surrounding missing medical records.

After a mix-up in the ER causes Conrad to deliver a death notification to the wrong family, he sets out to fix it. Meanwhile, Nic struggles to find a patient's records who has been under Lane's care, Devon forms a bond with an elderly patient and Mina is benched after overreaching in the surgical unit.

Three concurrent surgeries at the hospital push its staff to the limits. Determined to ease the pressure, Nic requests Jude for one of the operations, making Conrad jealous. Meanwhile, Dr. Lane Hunter sets out to discredit Nic's claims, Devon struggles with a patient who has an embarrassing problem and a charitable contributor comes to the hospital wanting to donate a lot of money to Dr. Lane's oncology program.

Conrad's ex-fiancé, Catherine, is admitted to the hospital with abdominal pain that proves to be quite the medical mystery. As Conrad doggedly tries to figure out her diagnosis and fights the idea of Bell performing her operation, Nic gets some insight into Conrad's past. Meanwhile, Bell panics when Claire announces that she will be installing cameras in all operating rooms, Devon wracks his brain for the perfect birthday present for Priya and Lane realizes that Nic is suspicious about her clinic.

Conrad is hit by a bike and badly sprains his ankle, but works through it when he takes the case of his old medical professor, who is hallucinating visions of her old patients. Devon is tasked with admitting Conrad, who refuses any sort of treatment. Nic tries to navigate her emotions while mourning the loss of a patient and Bell operates on a foreign dignitary with unforeseen complications. Meanwhile, Lane and Bell's relationship grows closer.

When Nic finds herself under investigation in Lily's death, Conrad comes to her defense, but ends up making the situation worse. During a routine surgery, Bell's patient accidentally catches fire, leaving the hospital to start an immediate investigation into his medical records. However, hospital CEO Claire Thorpe doesn't realize what she's up against when Bell plans a counter attack. Meanwhile, Devon deals with a series of ER patients, including a hypochondriac whom he fears could end up under Lane's care.

Devon and Conrad race against the clock to save the life of a woman who is deteriorating fast from undetermined symptoms. When the patient turns out to be a hero who helps previous criminals get their lives back together, the team relies on her family of ex-cons to help diagnose and treat her. Tensions rise as Nic continues her search for evidence to incriminate Lane, but must simultaneously tend to her sister, Jessie, who is rushed into the ER. Meanwhile, York returns to the hospital with his mother, who is in need of a risky procedure, and comes face-to-face with the stone-cold Dr. AJ Austin.

In a final and drastic attempt to save Nic from Lane's acts of sabotage, Conrad must call in a favor from the one person he promised he never would. Meanwhile, Mina's partnership with The Raptor takes on new colors when Micah is rushed back to Chastain with major heart complications and Dr. Bell's alliance with Lane is put to the ultimate test when one of her patients is readmitted.

A blackout at Chastain Memorial Hospital requires the staff to treat their patients without the help of any technology. Bell orders the staff to stop accepting new patients and transfer those on life support, but when a child in need is rushed to the ER, Conrad and Devon go against the mandate. Meanwhile, Mina and Austin are tasked with performing heart surgery on a premature baby, despite the lack of power, and Nic works tirelessly to organize the staff and patients who stay during the blackout.

Bell grows frustrated when Marshall Winthrop, Conrad's dad and new chairman of the board, requests Conrad's input in his discussions about the hospital's expenses. As Conrad and Nic work to cut costs for their patients in need, Julian Lynn, a sharp and sophisticated medical device rep, meets the staff at Chastain and inserts herself into the ongoing work of the doctors to promote her costly products. Meanwhile, Mina's relationship with Micah struggles in the wake of his healing process, and Devon is tasked with showing the eager new interns around the hospital.

Nic and Conrad contemplate their past when they team up to diagnose a happy husband and wife who are both admitted to the hospital with mysterious symptoms. Bell and Marshall butt heads on a work trip when their cut-throat business tactics don't align. Meanwhile, AJ turns down a request from Bell despite Mina's forewarning, Devon continues to gravitate to medical device rep Julian and the staff gears up for Conrad's three-year anniversary at Chastain.

Chastain is flooded with concert goers when a stampede at a music festival grounds leaves many in need of doctors. As Conrad and Nic race to help Josh Robinson, a professional adventure guide with a long list of prior injuries, Devon works with a musician who swears he is sober, even though his toxicology report suggests otherwise. Meanwhile, Bell stirs the pot when the hospital's revered orthopedic surgeon, Dr. Kit Voss, demands a better resident, Julian works to get her boss on Bell's good side and Winthrop continues to push Conrad to believe he's a changed man.

When Bell makes the executive call to utilize Julian Booth's medical devices, rather than the hospital's usual products, Kit and AJ must stop their momentary feuding in order to team up against him. Elsewhere in the hospital, Conrad and Nic work to make a child's dreams come true after finding out his cancer has returned and the rest of the staff takes notice of Julian and Devon's new friendship.

When patients from the hospital's prescription drug trial start suffering life threatening side effects, Nic fears that her sister Jessie may be in danger. As a result, she and Conrad work to convince Bell that these trials are not worth the risk. Meanwhile, Mina, Austin and Kit must set aside their competitive nature and work together on a patient whose health is quickly deteriorating and Devon uses Julian as the beta tester for a product he's designed.

Devon's doubts about his relationship reach a peak as his friends and family gather for his big wedding day. As Chastain's leading medical device company, Quovadis, continues to succeed, Julian makes a discovery that leaves her uneasy about her involvement in it all. Meanwhile, Conrad continues to work on his relationship with Marshall and Bell takes a risky offer in order to make a mistake from his past disappear.

When a nasty flu season turns out to be masking a terribly infectious disease, Chastain must race to quarantine and diagnose infected patients. Mina finds herself testing Quovadis medical devices in an effort to defend Dr. Austin, who, feeling responsible for the death of a patient, is serving penance by staying away from the OR. Conrad is prepared to take the next step with Nic, but finds that she may not be as ready.

Conrad, Kit, Mina and the Raptor work to save the life of a med student in need of a triple-organ transplant, drawing Bell back to the OR for one of the Chastain's riskiest surgeries yet. After the police find Julian's empty car in a nearby lake, Devon does some investigating of his own to find out what might have happened. Meanwhile, Mina and the Raptor hound Bell to halt his business with the risky medical device company, Quovadis, and Nic makes a rash decision regarding her sister.

When Conrad's attempt to surprise Nic with a lavish Valentine's Day dinner is foiled, he gives the reservation away to someone who could really use it. Mina and Devon distract themselves from all Valentine's celebrations by trying to figure out how their seemingly healthy neighbor has suddenly passed away. Meanwhile, Kit gives dating advice to a sex-injured patient, Irving hits a crossroads in his not-so-secret relationship with Nurse Jessica, and Bell decides to celebrate the day in the OR.

Bell's confidence in Quovadis continues to waver when the poster child for one of its medical devices, Henry Barnett, is rushed back into the ER, experiencing seizure-like symptoms. Meanwhile, Mina's past comes to light when her mother, famous Nigerian surgeon Dr. Okeke, pays a visit to Chastain, and Conrad makes a risky move when Henry returns to the hospital.

When Atlanta is struck by a severe snowstorm, Mina must perform a big surgery - without the help of The Raptor - to save the life of a young father, while Kit and Bell get stuck babysitting the man's children. Nic and Conrad experience a disagreement with a patient's treatment, causing further strain in their relationship. Meanwhile, Devon teaches an important lesson about life and death to a first-year med student.

When the hospital has a severe blood shortage, Conrad must try every avenue to save a patient's life. Nic receives devastating news and is left worrying about her sister's health, while Mina and Devon work with a new anesthesiologist who is not what she seems. Elsewhere, Kit considers the future of her intertwining relationships and Bell has an encounter with a woman from his past.

Bell hopes that a lottery winner who was admitted to hospital could serve as a way to solve Chastain's financial struggles; Nic is irate with Alec for suggesting she meet an organ broker; Devon and Irving help Mina remember certain details.

In an effort to save Chastain, Bell considers selling the hospital to a conglomerate, but Kit tries to make him see that the negatives will outweigh the positives. With Conrad's help, Nic tracks down Kyle and pleads for him to reconsider donating a kidney to Jessie. Meanwhile, Mina voices her concern to Austin when Shira is assigned to Micah's surgery and Devon fights for the care of a patient whom the doctors suspect is uninsured.

The doctors of Chastain are surrounded by new rules and doctors, as Red Rock Mountain Medical takes over the hospital. Conrad finds himself in a dangerous situation when the construction for a new neurosurgery center causes a gas explosion.

When a police officer brings in an injured criminal, the staff must keep him alive. Nic gets roped into a surgical rotation with Cain that leaves her questioning the way he operates. Conrad makes a shocking discovery about the hospital.

On National Nurses' Day, the nurses are severely understaffed and overworked. Cain performs a dangerous surgery on a new patient. Conrad discovers that his father has been administered the same drug that he fears played a role in Jessie's death.

The doctors work to save one of their own but disagree over what's best for her. Bell is met with an unexpected response when he voices concerns regarding the nursing shortage that Nic brought to his attention.

Devon and Irving are inundated with patients in the ER. When an A-list celebrity enters the hospital after swallowing a wishbone, Logan Kim assigns a new surgeon to the case in the hopes of garnering extra publicity.

Nic and Mina treat a patient battling a failing heart VAD, forcing them to find a new battery to save her life. Conrad gets a call from a patient who is in crisis. Cain tries to get close to Bell's business partner from the supplement company.

The new neurosurgery center opens, and Nic is forced to work alongside Cain again. Mina and The Raptor work together with a new surgeon on a heart transplant that has an unexpected result. Bell asks Conrad to reexamine three patients who may have been poisoned.

When Nadine's father comes to town for her birthday, Devon enlists help to ensure that he makes the best first impression. Red Rock decides to cut the entire OBGYN department. Nic cares for a teenage patient whose condition is deteriorating.

After a long wait, Conrad and Nic prepare for their wedding day with the support of their family and friends. Meanwhile, flashbacks to the early days of the COVID-19 crisis shine a light on the heroism of the doctors and the toll the virus took on everyone at Chastain Memorial.

When Cain’s elective surgery patient returns with complications, Mina and Raptor butt heads over how to handle the situation. Conrad and Devon treat a local Congresswoman who withholds information that could prevent her from receiving proper treatment, causing Devon to open up about his grief. In the wake of losing many colleagues to the virus, Bell worries who would be there for him in a moment of crisis and finds himself mining his own past to find his estranged former stepson, elite plastic surgeon Dr. Jake Wong. Meanwhile, Logan Kim finds himself on the chopping block when the doctors are questioned about his actions during the pandemic.

With Chastain on the verge of shutting down due to the sale by Red Rock, Conrad tries a last-ditch effort to save the hospital and the doctors plan for their next career moves. Meanwhile, on their last day, the whole staff must work together to save Nic's life after she is injured by a deranged patient.

As Nic struggles with her recovery, her close friend and former Chastain colleague, Billie, comes back to the hospital to support her. Meanwhile, as the hospital transitions from private to public, the search begins for a new CEO, Bell asks a favor of his step-son and Devon sees an opportunity to fix the system.

When Conrad gets a call from his former army commander who is stranded and wounded in the forest, the trip to save him brings lots of old emotions to the surface. Devon and Kit treat a patient who suffers from sickle cell anemia and encourage her to have a hip replacement to help treat her pain. Meanwhile, The Raptor is pulled away in the middle of an intense surgery, Mina is left to put her skills and finish the surgery on her own and Bell works on reconnecting with his stepson after helping him get hired at the hospital.

On Nic's first day back at Chastain, the man who attacked her is admitted to the ER, causing her to confront her trauma head-on. Cain, now in recovery, is self-conscious of his physical state and sets his eye on taking down Mina. The new intern both struggles and shines throughout her first day, causing Devon and Conrad to wonder if something bigger is going on.

A case becomes personal for the staff when Conrad and Bell treat a pregnant woman who is carrying Jake's future adopted child. Upon hearing surprising news from Princess Nadine, Devon contemplates the future of his love life. On the heels of meeting The Raptor's parents, Mina gets a call that causes her to make a bold decision about her future. Meanwhile, Cain grows closer to Rose and Irving and Jessica tie the knot.

Just when Mina and The Raptor can see their future together, an unexpected complication throws a wrench in their plans. Meanwhile, Cain faces a harsh reality when Kit gives him the opportunity to prove he is ready to return to the OR. Then, Devon presents Rose with a groundbreaking clinical trial that could help her battle with Sickle Cell Anemia.

When a tornado touches down in Atlanta with Chastain directly in its path, the entire staff goes into crisis mode. Conrad and Nic work on an injured EMT. Devon and Leela become trapped with a man who has severe head trauma.

With Nic's due date steadily approaching, she and Conrad plan a relaxing day off, but their plans are interrupted when a patient with a medical mystery sends them rushing back to Chastain. Devon stays by Rose's side as she starts her clinical trial and things take a turn for the worse. Meanwhile, Kit is under pressure to bring Chastain out of debt.

On the day of Nic's baby shower, Billie takes full control to make sure it goes smoothly, but a secret she's been hiding changes everything. Devon and Leela stumble upon an apartment fire, where they assist in getting victims safely to Chastain and Leela gets a chance to prove her skills to Raptor. Jake and his husband deal with the complications of Sammie's health. Raptor and Rose receive exciting news.

The wait is over as Conrad and Nic welcome the arrival of their baby girl. Raptor's life begins to fall apart and he is forced to turn to Cain for help. Devon and Bell work together on a complicated surgery that may allow them to save multiple lives. Kit tries to deal with the moral repercussions of financially saving Chastain.

When an accident brings a familiar patient into the Chastain ER, the doctors must face the reality of figuring out how to proceed with the best care, which leads the whole staff questioning every decision. Meanwhile, The Raptor and Leela deal with a patient returning with the long-term effects of COVID.

In trying to find a way to channel his emotions, Conrad puts all his effort in looking for answers. Raptor has a run-in with the police that ends up taking a surprising turn. Meanwhile, Leela begins noticing problems with a surgeon who has been Bell’s mentor.

While looking for a distraction on Halloween, Conrad treats a group of witches who send the ER into chaos. Also, Devon treats a patient who thinks he is being haunted by ghosts. Meanwhile, on the way back from his vacation, Bell picks up a hitchhiker who is not what he seems to be.

Conrad brings a patient into the hospital who causes a high security crisis. An MMA brawl sends a well-known fighter to Chastain and all hands are on deck. Meanwhile, Bell and Raptor vie for the same position at the hospital, and Leela gets a visit from her sister.

Kit hires a surgical coach to watch over Bell and Raptor and help them brush up on their skills. Upon receiving attention from multiple women at the hospital, Conrad contemplates jumping back into the dating scene. Meanwhile, Devon works with an elderly couple.

Conrad takes Trevor under his wing to care for a patient whose good luck seems to have run out. Leela struggles when given the decision to take full responsibility of her indecisive patient's life and The Raptor continues to try to figure out a care plan for his mother. Meanwhile, both Devon and Kit are stretched far too thin trying to balance everything on their plates

When the first day of Kit's experimental Flight Go team program sends Conrad out into the field, he builds a new relationship with a fellow doctor along for the ride. Devon works with Trevor for the first time on a patient with a mysterious fever, the cause of which can't be found. Meanwhile, Bell is hiding a secret from the whole staff and they are starting to become suspicious.

A tragic accident occurs at Jessica’s sister’s gender reveal party, putting her brother-in-law’s life in jeopardy. Meanwhile, Conrad, Irving & Trevor work on an influencer whose life was put in danger by a risky cosmetic surgery. Then, Bell is cleared for his first surgery back and Billie is forced to face her past head-on.

When things from Billie's past begin to come to light, she is the subject of whispers and stares around the hospital and the team struggles to find the best way to support her. With the nurse shortage in full swing, a simple cleaning job turns into a horrific disaster that calls for all hands on deck. Meanwhile, Trevor discovers a shocking secret and Padma has a proposal for Leela

Conrad treats one of Gigi's fellow classmates whose stomachache turns into something much more serious; Devon takes several interns to a senior living facility; Leela uncovers some unsettling news.

When one of the doctors is shot outside the hospital, the ER is put into lockdown and the team races to save one of their own. Elsewhere, Devon and The Raptor work with a patient who learns he is unable to receive a lung transplant, due to his vaccination status. Meanwhile, Devon and Leela try to juggle the new dynamics of their relationship and Cade's father arrives at Chastain.

Conrad contemplates his future; Devon is presented with an amazing career opportunity out of state; Ian is faced with a devastating diagnosis; Kit and Bell celebrate their engagement; Padma receives some highly anticipated news.

When Padma's pregnancy takes a dangerous turn, the doctors come together to find a solution and turn to Ian to perform a miracle. Meanwhile, Conrad makes a decision regarding his love life and Devon leads his own clinical trials at Chastain.

The high stakes governor election results in violence at the polls, causing multiple victims to arrive at Chastain. Conrad finds common ground with an aggressive patient, helping lead to a diagnosis for his outbursts. Meanwhile, when another patient’s lung collapses, the doctors find a serious root of the issue.

When a gunshot victim comes into the ER, his injuries prove to be so catastrophic throughout his body that multiple doctors need to jump on the case. Meanwhile, Ian is faced with a mandatory drug test and Padma prepares for her C-section.

Ian is faced with performing a surgery on a Jane Doe NICU patient while he continues to struggle with his personal issues. Meanwhile, Conrad asks Devon to cover his shift so he can spend a day at home with an anxious Gigi.

A college professor comes into the ER and Conrad realizes it’s a former patient of his from when he was an intern. Meanwhile, Devon ends up admitting a man – who swears by an anti-aging regimen that he thinks is the answer to eternal life – into the hospital after he collapses.

On the day of Kit and Bell’s wedding, Bell and Conrad get pulled away to tend to the ill daughter of a major hospital donor. Meanwhile, Billie takes Gigi and Sammie dress shopping.

Devon sees a traveling British couple who are nervous about the cost of American health care.

After a teenage boy is taken into Chastain for falling unconscious from a suspicious pill, Conrad takes action to find the boy's brother before he meets the same fate. Meanwhile, Dr. Bell deals with being served court papers from a former patient.

Conrad comes face to face with Nic's dad, Kyle, after 5 years of no contact, when he comes into Chastain with an extremely low heart rate. Billie advises her patient against surgery, but the patient’s family ignores her recommendation. Meanwhile, Cade musters up the courage to confront Ian about his addiction and Leela grows concerned about Padma.

A famous cardiothoracic surgeon – who happens to be Dr. Yamada’s mentor – comes into Chastain after experiencing heart pain. Meanwhile, Kit breaks the news that the ER will no longer be accepting trauma patients due to budget cuts, and Devon and Conrad help treat a confused woman.

Conrad is pulled away from celebrating Gigi’s 6th birthday when Sammie comes into Chastian with a 104-degree fever, and Kit must call in a favor for treatment. Meanwhile, a heart arrives for Governor Betz’s transplant surgery.