When Spider-Man and Max Modell experiment on a sample of Venom symbiote, it escapes and unleashes a weapon of unknown purpose.

Symbiotes from space send an advanced hunting party to Earth to take out all of the superheroes; Spider-Man must team up with Marc Spector and Max Modell to save the planet.

After Aleksei is turned back into the rampaging Rhino by Swarm, the Spider Team must battle for their lives in the Underground Monster League contest.

Spider-Man discovers Norman Osborn is responsible for the Venom Symbiote's escape; Norman, aka the Dark Goblin, brings the Generations team to battle against Spider-Man.

When Spider-Man and his allies attempt to track down the missing and dangerous Lizard, they discover that Venom has returned to seek revenge on the earth.