Transplant patient and now doctor, Frankie starts her first day in Renal rotation; best friend Lou battles surgery's boys' club; and flatmate Tabb starts as an intern.

Frankie takes on the system to save a patient, and lands in trouble. Lou finds out it’s not always wise to have an affair with a boss; and Tabb questions his ability as a doctor.

When a heart transplant patient dies, Frankie fears the surgeons will close ranks to cover up a medical error. Lou realises she and best friend Frankie may be on different sides.