A young boy prostitute is butchered on the Williamsburg Bridge, alienist Laszlo Kreizler, newspaper illustrator John Moore, secretary Sara Howard & police commissioner Theodore Roosevelt investigate outside the law to find a serial killer.

Innovative evidence leads the team to discover a crucial element in the case is missing. Kreizler and Moore interview a witness to find out what happened to Moore at the Brothel. Sara attempts to live in a world outside the investigation. Kreizler challenges them to look within themselves.

Kreizler mourns the loss of a friend. Sara pushes the team to forge ahead. Moore warns his friend the killer will strike again. Cyrus seeks revenge.

Kreizler confronts the demons of his past. Moore tells Sara the truth. Connor takes matters into his own hands. The team closes in on the killer as time is running out.