Sheldon and Missy both run away from home, and Mary gets upsetting news about George Sr.

Sheldon encourages Missy to question the Bible. Also, Connie is determined to catch George Sr. in a lie, and Mary helps Pastor Jeff search for a youth pastor.

Sheldon tries to convince Dr. Sturgis to return to the university. Also, Georgie upsets the family when he makes a life-changing decision.

Sheldon, Missy and Georgie adapt to new living arrangements. Also, Connie opens a gambling room.

Sheldon and Dr. Linkletter struggle to solve an equation. Also, Georgie has a solution for Connie's business woes, and George Sr. gives advice on Missy's love life.

Missy asks some uncomfortable questions at church, and Connie and Georgie go into business together.

Sheldon takes his first engineering class with Professor Boucher. Also, Meemaw and Dale help take care of his ex-wife, June.

Sheldon battles President Hagemeyer's mysterious boss over the university's science requirements. Also, Mary discovers that Georgie is working at Connie's illegal gambling room.

Sheldon gets the science yips and has to learn how to not think. Also, George Sr. plays handyman at Brenda Sparks' house.

Sheldon gets a dorm room all to himself. Also, Connie gains an unwanted business partner.

Sheldon acts as Mary's spy during a youth lock-in at church. Also, Georgie is attracted to an older woman, Mandy.

Sheldon attends his first comic book convention; Mary tries selling makeup.

Sheldon makes friends with his dorm neighbors; George Sr. learns his job is in jeopardy.

Sheldon butts heads with Dr. Lee, a new scientist in the lab. Also, Mary is given a lotto ticket.

Sheldon joins Dr. Linkletter and Dr. Sturgis on a science road trip. Also, Georgie continues to lie about his age.

Connie's gambling room is a success, and Sheldon dips his toe in the stock market. Also, Missy starts a business.

Sheldon gets an odd request from an old friend, Paige. Also, George Sr. and Mary are caught in the middle of Connie and Dale's breakup, and Georgie comes clean to Mandy.

Sheldon copes with the death of a hero. Also, Missy wants to babysit, and Georgie struggles with his big secret.

George and Mary insist on meeting the new woman in Georgie's life. Also, Sheldon and Missy have suspicions about what's going on with their family.

Sheldon and Missy learn about Georgie's pregnancy, and the whole family promises to keep it a secret.

As the church congregation gossips about Georgie, Missy stands up for her brother, and Sheldon is distracted by the family drama.

Sheldon struggles to cope with the first signs of puberty. Also, Mary and George Sr. hunt for new jobs, and Georgie and Meemaw take a business trip across the border.

George Sr. bails Connie and Georgie out of jail. Also, Sheldon and Missy meet Mandy, and Mary feels unwelcome at church.

Sheldon and Missy try to help the family’s finances. Also, Mary struggles to find her footing without the church.

Sheldon must choose sides in an ethical dilemma. Also, Mary tries her hand at writing and Mandy needs a new place to live.

Sheldon makes a terrifying mathematical discovery while tutoring Billy. Also, Mary is jealous of Missy's relationship with Mandy and Connie.

At college, Sheldon decides to expand his responsibilities and become a dorm resident advisor. Also, Connie and Dale make a sketchy business deal, and Mary and George Sr. rekindle their romance.

George Sr. is asked to help with the football team. Also, Mandy discovers Georgie and Connie's secret business.

Sheldon's search for a comic book leads him to a breakthrough. Also, Georgie and Mandy have an uncomfortable first encounter with her parents, Jim and Audrey.

Sheldon's database invention puts him at odds with the university. Also, the church takes issue with Connie's video store.

Sheldon considers dropping out of college to focus on building his database. Also, George Sr. is frustrated when someone else gets credit for his football wins.

Mary struggles to make new friends while Mandy pushes Georgie to date another woman.

Sheldon learns the university is building a database without him. Also, Mary takes care of a bedridden Mandy and Meemaw.

Mary butts heads with Mandy's mother, Audrey, and Sheldon attempts male bonding.

Paige drags Sheldon to a college party and Missy gets caught in a lie.

The Coopers can't be found as Mandy goes into labor. Also, Sheldon is excited about the launch of his database.

Sheldon confronts the failure of his database. Also, Georgie and Mandy struggle as new parents and Missy feels forgotten.

Missy steals her dad's truck and hits the road with her friend Paige.

Georgie goes on a birthday date and Mary confronts Brenda about her relationship with George. Also, Sheldon takes an interest in Missy's favorite TV show.

Sheldon wants to search for life on other planets and Mandy answers Georgie's marriage proposal. Also, Missy is caught between two friends.

Mandy gets an exciting job opportunity and Sheldon worries that he's falling behind. Also, Georgie takes his daughter to work.

The gambling room gets broken into and Sheldon wants to study abroad. Also, Missy makes a new friend.

Mandy surprises Georgie with a spa weekend and Sheldon prepares for his summer in Germany.

Sheldon and Mary head to Germany while the rest of the Cooper family braves a tornado that is heading straight for Medford.

News of the tornado reaches Sheldon and Mary in Germany. Also, with the Cooper house in chaos, Missy steps up.

Sheldon realizes he is the weakest student in his class; Meemaw is looking to expand her gambling business.

Sheldon explores Germany behind Mary's back, Missy attempts to pull a fast one on George Sr. and Meemaw and Dale adjust to living together.

Missy steps up, Mary has a surprise for George, and Sheldon finds his dorm occupied.

Sheldon helps his roommate try to beat the stock market, Missy and Billy Sparks throw a party, and Mary finds a new church.

Georgie and Mandy's wedding plans pit Mary against Mandy's mom, Audrey, with baby CeeCee caught in the middle.

Georgie and Mandy get married! Meanwhile, Meemaw's gambling room gets raided.

Sheldon studies to be Meemaw's lawyer when she is put on house arrest, and the Coopers have a plumbing emergency.

Sheldon's published paper leads to a frenzy of grad school recruiting, and Georgie tries to speak more properly in front of his daughter.

Connie gets assigned a tough probation officer, and Georgie takes marriage advice from his father-in-law.

George Sr. is worried that Mary wants another baby and gets a vasectomy behind her back. Meanwhile, Drs. Linkletter and Sturgis go to Sheldon for science tutoring.

George Sr. gets an exciting job offer, and Sheldon prepares for his move to California.

The Cooper family grapples with the death of George Cooper Sr.

Sheldon leaves East Texas for the California Institute of Technology following the death of his father.