9-year-old Sheldon Cooper is a once-in-a-generation mind capable of advanced mathematics and science but learns that isn’t always helpful growing up in East Texas, a land where church and football are king.

To appease his worried mother, Sheldon employs the techniques of a self-help book to try and make a friend.

When a NASA representative visits Sheldon’s school and dismisses his science, Sheldon is set on a mission to prove him wrong.

When flu season hits Medford, Sheldon takes extreme measures to remain healthy.

A disappointing loss at the science fair sends Sheldon’s life in a new direction.

Sheldon studies his family for a psychology project. Thanksgiving dinner turns into a family fight when George Sr. is offered a job in Oklahoma.

Sheldon attempts to build a nuclear reactor. Also, a university cocktail party gets heated when Dr. Sturgis’ colleague, Dr. Linkletter, flirts with Connie, and Georgie is heartbroken when he learns Veronica has a boyfriend.

Sheldon uses his new friendship with the school bully to boss Georgie around. Also, Missy steals Connie's makeup for picture day.

Things spiral out of control when Sheldon boycotts his favorite bread company. Also, Georgie offers Veronica a shoulder to cry on when she's dumped by her boyfriend.

Unhappy that school funds are going towards football rather than academics, Sheldon decides to run for class president.

The Coopers help Pastor Jeff through a rough patch in his marriage. Also, Sheldon pressures church members for donations when Mary takes him to work for a day.

Without Dr. Sturgis’ university class, Sheldon must find a new way to stay academically challenged. Also, Mary helps Pastor Jeff avoid temptation with his girlfriend.

The University makes George Sr. a lucrative job offer in the hopes of recruiting Sheldon. Also, Georgie gets a job working for Connie's new boyfriend, and Mary is determined to rid her home of greed.

Sheldon fakes being sick to avoid a swim test at school. Also, Dr. Sturgis spies on Connie's new boyfriend.

When Sheldon learns the house next door is for sale, he takes it upon himself to find the perfect neighbors. Missy is torn when she’s forced to pitch against her boyfriend at the baseball game.

Sheldon discovers that Mary's been keeping a secret about his future. Also, Connie is furious when she learns Dale fired Georgie.

Sheldon, Dr. Linkletter and Connie team up on a science experiment. Also, Mary is jealous that Pastor Jeff and Brenda are spending time together, and Georgie has a new side hustle.

Sheldon is caught in a moral dilemma when offered a bootleg copy of a computer game he can't afford. Also, Mary and Connie take Brenda out for girls' night while George Sr. and the guys watch Billy, and Missy asks Georgie to take her and Marcus on a secret date.

Sheldon attends his first comic book convention; Mary tries selling makeup.

Sheldon considers dropping out of college to focus on building his database. Also, George Sr. is frustrated when someone else gets credit for his football wins.