As Shaun pushes back against Dr. Melendez in order to treat a gravely ill hospital janitor, Dr. Lim risks a lawsuit to repair a teenage girl’s ritual circumcision. Dr. Glassman exercises demanding oversight in choosing a doctor for his brain surgery.

The hospital is still in quarantine as Dr. Shaun Murphy continues to be overwhelmed by the chaos and noise in the emergency room; Dr. Morgan Reznick struggles to keep her patients alive, and Dr. Audrey Lim fights for her life. Meanwhile, Dr. Neil Melendez and Dr. Claire Browne must find a way to complete their patient’s bone marrow transplant, despite the quarantine.

In the aftermath of the quarantine, the staff tries to return to their normal routines. Meanwhile, as Dr. Lim recovers from the virus, she and Dr. Melendez navigate their new personal and working relationship, while Dr. Murphy and Dr. Glassman visit Lea.

Dr. Murphy treats a patient who has an illness that is not only unpredictable in nature, but also unlike anything he or the team has seen before. Dr. Claire Brown continues to work through her grief, still reeling from Dr. Neil Melendez's death.

Shaun has a hard time balancing his fears and concerns about potentially jeopardizing Lea's health and wanting to be with the woman he loves. Claire looks for a way to grieve Melendez's death. Park and Mia discuss their future together.