Shaun’s blunt honesty with a distraught mother of a critically ill newborn baby causes the new chief of Surgery to question keeping him on as a resident.

When Dr. Shaun Murphy makes an emotional confession, the result may not be as desired. Meanwhile, he becomes obsessed with performing an autopsy on a Jane Doe, which challenges his relationships at the hospital; and Dr. Claire Browne, Dr. Morgan Reznick and Dr. Marcus Andrews treat a male college student with a mysterious split personality disorder.

When the hospital is hit with a cyberattack threatening to shut down life-saving machines, Lea rises to the challenge and looks to outsmart the hackers to prove herself. Meanwhile, the team treats an inspirational cancer survivor-turned-successful-philanthropist who harbors a dark secret.

Shaun struggles to accommodate the newest member of his surgical team, Charlie, who interferes in a patient’s relationship with his daughter. Elsewhere, Park tackles a tricky brain tumor, and Lea and Morgan adjust to motherhood.