Reese, Chad and Joe chase Durkee, a wanted man, into Captain Parmalee's office only to find out he is seeking amnesty in return for information about the Jamison Gang. The three of them are assigned to work with him and sent to Arillo. Meanwhile, Sam Burns is trying to force Annamay, a widow with two children, off her ranch so he and Jamison can get the silver bars the Gang buried in her barn's floor. The Rangers help Annamay and the children repair her wagon wheel and she takes a liking to Reese, who the children are soon calling ""Uncle Reese"". Annamay learns of the silver and switches it to a new hiding place. Jamison and Gang threaten Annamay and the children as the Rangers hurry to rescue them and recover the silver.

Reese, Chad and Joe capture the Slaughter Gang and take them to the nearest jail in San Sabo. They take the stolen money to the bank and meet Miss Emma there, who is a cultural lecturer selling tickets for her lectures on Greece with little luck. Chad and Joe trick Reese into helping her. He does so by employing saloon dancer Carlotta to warm up the crowd for Miss Emma's lecture. While Miss Emma is speaking a gang robs the bank and releases the Slaughters at the same time to throw suspicion on them. While pursuing the robbers Reese crosses paths with Miss Emma and discovers there may be more then meets the eye concerning the ""wealth"" of her wagonload of books.

Reese and Cotton run off two outlaws intent on forcing the inhabitants of San Diablo to divulge where the fabled treasure is hidden. Dandy Davis is wanted and Cotton heads back to Laredo with him but Dandy fills Cotton's head with stories of the treasure and how Reese will beat him to it. Reese has stayed behind as he knows the other outlaw Ben Slick will be back to raid the town and the San Diablo citizenry has asked him to teach them to defend themselves. Reese becomes general of their ""army"" and is even given a uniform. When the outlaws return Reese and the citizens defeat them and Reese and Cotton are able to return to Laredo.

Joe is on a stage that is held up by Indian Pete's gang and their only intent seems to have been trying to kill a 9 year-old girl passenger. The stage arrives in Laredo and the girl is dismayed to find out it doesn't continue to San Remo where she is going to live with her Uncle Charley. Reese, Chad and Joe go to draw their pay but are overdrawn so Parmalee gives them $5 each as a loan. They lose it at the saloon playing double or nothing so the girl, Gussie Smith, offers to pay them to take her to San Remo. Since they are broke on their weekend off they accept the girl's $10 offer. Captain Parmalee has also warns them to be on the lookout for a character who is passing bad checks. They arrive in San Remo, a near ghost town, and Chad goes to ask the sheriff where Charley Smith's place is. The sheriff turns out to be a gunfighter who murdered one of Chad's friends years ago. After being kicked off the land by ""Uncle Charley"" and shot at the Rangers discover the real Uncle Charle

Chad, Joe and Cotton Buckmeister are offered a $50 bonus to transport a bottle of Nitro Glycerin and the Professor who invented it to an army fort. A quick-change artist keeps trying to steal the Nitro and eventually succeeds. The Rangers manage to capture him and get the Nitro back.