It is raining on Wisteria Lane, six months after Mike was run over. He is now in a coma, with Susan by his side. Bree gets engaged to Orson. Gabrielle and Carlos are getting divorced, but they are briefly reunited when their 8½ months pregnant surrogate Xiao-Mei runs away. While adjusting to having another child around the house, Lynette realizes that the girl's mother, Nora, is more than she can handle.

Gabrielle struggles with the reality of having a blind husband. Lynette is surprised when Rick Coletti shows up at the Scavo pizzeria. Bree and Katherine join forces to plan the Founders Day Ball. As part of his recovery, Mike asks a few people for forgiveness, and Orson starts sleepwalking.

Susan and Mike try to name their son. Lynette is arrested for supposedly attacking Kayla, and Tom must do what he can to save his family. Bree is being stalked by Orson, and when she meets with Reverend Green, the reverend tries to hit on her. In the meantime, Gabrielle is still helping the police trying to detain Ellie for dealing drugs. Finally, Katherine is visited by her ex-husband, Wayne.

Driven by a hidden agenda, Dave convinces Susan to throw Mrs. McCluskey a surprise party for her 70th birthday. Jackson wants to take his relationship with Susan to the next level. Gabrielle's concerned she might be pregnant. Tom tells Lynette he's sold the pizzeria. A startling reason for the bond between Bree and Katherine is revealed. And finally, an outraged Mrs. McCluskey has the entire neighborhood questioning her sanity.

Susan is forced to reveal her secret to Mike; Juanita becomes suspicious of Gaby's interest in Grace; Lynette is worried about Tom's mother's memory lapses; Bree learns a secret about Keith; and Paul takes Beth out on a date.

Susan vows to get the most out of life when she learns that her dialysis isn't working and that, unless she receives a kidney transplant soon, she will die. Meanwhile, jealous of Lee and Bob's adopted daughter's routine for an upcoming school talent show, Gaby pressures Juanita to come up with a number that will outshine everyone; Bree makes it her mission to find a kidney donor for Susan; Lynette puts a plan into action to discourage a clearly non-maternal Renee from adopting a baby; and Beth Young struggles to figure out what to do with her life after Paul kicks her out of the house.

Bree is stunned when she learns who dug up the body of Gaby's stepfather; jealousy rears its ugly head when Lynette begins to spread untruths to daughter Penny about Tom's new girlfriend; Gaby and Carlos must convince Lee and Bob that Juanita and Celia aren't the bad seeds that they used to be when they want to name them in their will as guardians; and Susan desperately searches her inner self to find what inspires her in order to better her art and impress her hard-to-please art teacher, Andre.