Lynette is angry when Renee starts spending a lot of time with Tom; Bree finds herself falling for Keith (Brian Austin Green); Susan feels guilty about her side job.

Susan is less than pleased when she finds out that some of her best and sexiest internet show moves are being copied by a competitor (guest star Rebecca Creskoff), and Gabrielle hires a private detective to look into an important matter, unbeknownst to Carlos. Meanwhile, Lynette is stunned when Tom's doctor prescribes him a rather unorthodox remedy for his depression, and Renee invites a reluctant Bree to go clubbing with her in order to engage in some local man-hunting.

Susan is horrified when she discovers that she has become the face of the provocative internet company she's been secretly working for and is now the cover model for their outdoor billboard ads; Gabrielle tells her coveted secret to the ladies; Renee finds out that Bree is a grandmother and uses it to her advantage in an attempt to steal Keith away and have him for herself; Lynette takes advantage of daughter Penny's generous offer to help look after the baby; and Paul purchases the home he shared with Mary Alice, against wife Beth's wishes.

Susan is forced to reveal her secret to Mike; Juanita becomes suspicious of Gaby's interest in Grace; Lynette is worried about Tom's mother's memory lapses; Bree learns a secret about Keith; and Paul takes Beth out on a date.

A reluctant Susan accepts Lynette's offer to be baby Paige's nanny; Bree meets Keith's parents; Renee makes a proposal that Lynette can't refuse; Gaby fears that Bob might be trying to seduce Carlos after they become friends; and Beth begins to question Paul's motives for returning to Wisteria Lane.

Thanksgiving on Wisteria Lane finds Gabrielle and Carlos hosting Carmen, Hector and Grace to a bountiful feast. But the Solis's discover some surprising news about the Sanchez's that could threaten their time with Grace.

Meanwhile, Bree invites Keith's parents to partake in Thanksgiving at her house and learns some family secrets; Susan butts heads with Lynette over her sleep training techniques for baby Paige; Renee continues to remind Tom about their past; and Beth tries to uncover more about Paul's past misdeeds.

Paul's nefarious plan for Wisteria Lane is put into full effect. Juanita discovers that she isn't Gabrielle's biological daughter, and Bree invites Keith (guest star Brian Austin Green) to move in with her, whilst Tom is confronted about his past indiscretion with Renee.

Paul finds out that Beth is Felicia Tilman's daughter while a therapist asks Carlos and Gabrielle to erase Grace from their lives. Susan finds out she needs to go to the hospital every 48 hours and Renee finally tells the secret between her and Tom to Lynette. Orson returns and Bree gets torn apart with her feelings between Orson and Keith and detectives try to find the person responsible for shooting Paul Young.

Susan's mother and aunt visit her at the hospital, Lynette plots revenge against Tom, Gabrielle becomes increasingly obsessed with getting Grace back and Bree wants to be friends with Beth.

Lynette feels her mother (guest star Polly Bergen as Stella) is marrying Frank (guest star Larry Hagman), an abrasive and obnoxious man, for all the wrong reasons, and thus tries to talk her out of it. Meanwhile, Carlos becomes concerned when he learns about Gabrielle's obsession with her doll, and Bob and Lee hire a non-maternal Renee to decorate their newly adopted girl's bedroom. Bree runs into Keith's ex-girlfriend (guest star Rochelle Aytes as Amber) and learns some shocking news about his past, and Susan tries to befriend a curmudgeonly man (guest star Gregory Itzin as Dick) who has given up on ever finding a kidney donor. In the meantime, Paul appears to have some plans for Beth (guest star Emily Bergl), as he books a trip for the two of them to a remote cabin in the woods.

Gabrielle and Carlos head to Texas to visit Gabrielle's stepfather's grave; Lynette prohibits Porter and Preston from bringing home prostitutes; Renee tries to use Susan's dialysis to help her get into a restaurant, but fails.

Susan vows to get the most out of life when she learns that her dialysis isn't working and that, unless she receives a kidney transplant soon, she will die. Meanwhile, jealous of Lee and Bob's adopted daughter's routine for an upcoming school talent show, Gaby pressures Juanita to come up with a number that will outshine everyone; Bree makes it her mission to find a kidney donor for Susan; Lynette puts a plan into action to discourage a clearly non-maternal Renee from adopting a baby; and Beth Young struggles to figure out what to do with her life after Paul kicks her out of the house.

Paul tries to stand between Susan and her kidney transplant; Felicia is released from prison and swears revenge against Paul; Gabrielle is furious about a neighborhood party planned by Renee; Tom is caught between working with Carlos and a job opportunity; Andrew's drinking concerns Bree.

Everything that begins must eventually end. This episode of beginnings and endings walks us both backwards and forwards as we take our final stroll down Wisteria Lane.