Tom versucht, sich bei seinem Chef Ed einzuschleimen, merkt jedoch nicht, dass sein Vorhaben nicht gut ankommt und Ed ständig Witze über Tom reißt. Lynette findet schnell einen Weg, Ed davon abzuhalten. Susan ist derweil verzweifelt: Sie braucht dringend eine Krankenversicherung für ihre bevorstehende Milz-Operation.

Edie thinks that Karl is going to pop the question after she finds an engagement ring and prenuptial agreement in his briefcase. Also, Gabrielle and Carlos learn she is highly unable to conceive a child again because of complications caused from her recent miscarriage. Lastly, Bree's problem with alcohol intensifies with the notice of Lynette after Bree babysits her children.

Lynette is called in to her kids' school as Parker has gone from being obsessed with Dinosaurs to being obsessed with nudity. Carlos and Gabrielle must go to court to get custody of their baby. Bree's father Henry and stepmother Eleanor come to town to mediate between Andrew and her. Susan is convinced that Karl doesn't really love Edie. Later, she goes to a movie theater, and spots Mike with a date.

Um ihr Gewissen zu erleichtern, schreibt Susan Edie einen Brief, in dem sie das Techtelmechtel mit Karl gesteht. Sie ahnt nicht, dass Mike den von Edie engagierten Privatdetektiv bezahlt hat, um ihr Geheimnis zu bewahren.

Reaching the end of her rope, Bree checks herself into the Fairview psychiatric hospital. Lynette suspects that Tom is cheating on her, so she follows him to Atlantic City. Susan must start over. Felicia Tilman has more in store for Paul Young, resulting in their war reaching its final battle. Gaby and Carlos get Xiao-Mei pregnant.

Flashbacks take us back to to moving-in day on Wisteria Lane for Bree, Lynette, Susan and Gabrielle and how Mary Alice brought them all together. Back in the present, Bree gets some frightening news. Susan moves into a trailer after her house was burnt down. Lynette and the kids are staying at a hotel. After seeing a report on the news, Gabrielle believes Carlos died. Paul begs Zach to get him a good lawyer via Noah.

Auch sechs Monate nach Mikes Unfall weicht Susan im Krankenhaus nicht von seiner Seite. Da macht sie die Bekanntschaft von Ian, dessen Frau ebenfalls im Koma liegt. Während Bree und Orson glücklicher denn je sind, muss sich Lynette mit Nora, der Mutter von Toms unehelicher Tochter Kayla, auseinandersetzen.

It's wedding day for Bree and Orson but things don't go quite as planned. Meanwhile, the body of a dead woman believed to be Orson's ex-wife is recovered, which interrupts the reception. Susan goes on a date with Ian, but trouble ensues when his in-laws show up at the restaurant. When Nora breaks up with her boyfriend, Lynette decide to hook up Nora with someone. Edie lets her 18-year-old nephew Austin come live with her for some time. Lastly, Xiao-Mei goes into labor.