Gabrielle kisses Tom and Lynette is not happy and drives a wedge in her friendship with Gabrielle. Paul attacks Mike. The housewives become more suspicious of Betty and her family. Andrew is trying to blackmail Bree, but Bree gets some assistance from Susan's ex, Karl.

Bree and Andrew finally reach an impasse in their relationship as tension has finally reached a critical point. Meanwhile, Ed finally fires Tom with the pressure from his wife. Lastly, Edie's private detective begins to uncover numerous details of Karl and Susan's relationship as of recently. Gabrielle is having a tough time keeping her servant in the country.

It is a holiday weekend on Wisteria Lane. Bree and Orson are going on their honeymoon, while Gabrielle and Lynette are going a spa vacation and Tom is going on a camping trip with the kids. Meanwhile Susan is going on a quiet romantic getaway with Ian, not sure if she's cheating on Mike. However, things don't go as planned.

Lynette returns home from the hospital. Gabrielle decides to get back into modeling and travels to New York. Susan comes home to find Austin and Julie making out on her couch. Bree meets her antagonistic mother-in-law Gloria, with whom Orson is in a quarrel. Detective Ridley has Mike's house searched.

Susan goes to the therapist and realizes she must choose between Ian and Mike. Travers is having a birthday party which only spells trouble for Mrs. McCluskey, Gabrielle's engagement party is upstaged by an unexpected announcement and the neighborhood is full of gossip about the dead body found on Wisteria Lane.