The new neighbors, the Applewhites have moved in. Gabrielle, Lynette, and Susan attempt to comfort Bree while Rex's mother arrives on Wisteria Lane for his funeral. Meanwhile Mike and Susan deal with Zach while Gabrielle struggles with the two men in her life.

Susan is surprised when she finds out who Edie's new boyfriend is. Meanwhile, Lynette has gone back to work, leaving Tom at home in charge of the house. Carlos makes an unusual request to Gabrielle after his life is threatened behind bars. Lastly, pharmacist George reemerges in Bree's life, which sets off an alarm to mother-in-law Phyllis and her suspicions surrounding her son's death.

Susan tries bravely to accept Edie’s new role in Julie’s life, while Lynette’s demanding boss makes her miss Parker’s first day of kindergarten. Bree later on takes a polygraph test to prove her innocence in Rex's death and realizes she has feelings for George.

Gabrielle finally comes to the truth about Carlos and John after seeing John with another woman.

Edie is shocked when she receives some news at the gynecologist's office. At the baby shower Bree's friends throw her, Bree's ex-mother-in-law Phyllis discovers her pregnancy is a hoax. Finally, Wisteria Lane welcomes to the street a homosexual couple.

Bob & Lee's contemporary water sculpture in their front yard prompts the Wisteria Lane neighborhood association into action. Edie finds out about the affair that Carlos is having with Gaby. Also, John Rowland wants to rekindle his romance with Gaby.