A break-in on Wisteria Lane leaves the neighbors feeling vulnerable, especially Susan, who reluctantly accepts a date with a persistent policeman after Mike appears indifferent to her. Rex takes the kids away for the weekend as a lonely Bree finds herself bonding with Zach. Meanwhile, Lynette and Tom pull out all the stops to get their uncontrollable twins Porter and Preston accepted at a prestigious private school, and the unexpected arrival of Carlos' mother puts a crimp in Gabrielle's covert love life.

The residents of Wisteria Lane finally learn Martha Huber's fate. After learning that Mrs. Huber left behind a journal, Susan is forced to confess to Edie about her role in the fire that burned down Edie's house. Meanwhile Bree finds her new beau, George getting a little too close for comfort. Lastly, Carlos returns, but his homecoming isn't quite what Gabrielle had in mind. He is under house arrest, making it difficult for either of them to make money.

Mike Delfino is questioned about Mrs. Huber's murder by police and is arrested. John's friend, Justin attempts to blackmail Gabrielle with his knowledge of their affair. Meanwhile, Tom wants a big promotion, but Lynette fears that she'd be home alone with the kids more than ever and tries her best in discouraging him in taking the job. Also, Bree is shocked when she finds a condom. Zach Young plans a pool party for the teens on Wisteria Lane, and things get out of hand. Finally, someone comes out of the closet.

Lynette learns that no good deed goes unpunished when she momentarily befriends the mean Mrs. McClusky. Susan's mother decides to try and jump start her and her daughter's love lives. Andrew talks to a priest about his feelings, and tells him of his shocking plans for his mother, Bree. Gabrielle has her credit card declined in an upscale restaurant, and Carlos sends Gabrielle a big message about what will happen if she leaves him.

Bree begins to feel guilty about her friendship with George while Rex's health continues to depreciate. Lynette tries to spice things up with Tom who, she fears, is losing interest. Meanwhile, Mr. Shaw consults with Paul, and ends up lying to Susan. After talking with Kendra Susan learns what Mike did. Gabrielle tells John that she is pregnant, and John doesn't take the news well. Lastly, Felicia takes action to help Zach, and to get rid of Paul for good.

After a number of bad dates, Susan finally meets Dr. Right. Susan flirts with a handsome doctor, but they accidentally head butt. Meanwhile, some old pictures of Gabrielle turn up on the Internet. Tom is alarmed when his kids come down with chicken pox because he never had it. Bree gets arrested. Lastly, after months of silence, Noah Taylor contacts Mike Delfino.

Tom tries hard to bond with his new boss and tries to get Lynette to help him out. Meanwhile, Susan gets some help from Edie and Karl on her situation of getting health insurance before her upcoming surgery. Gabrielle becomes very attached to a temporary Chinese immigrant housekeeper who is staying with Solis' after being rescued by another slave owner employer. Lastly, Bree tries to uncover more about the Applewhites by sneaking into their house to meet Caleb.

Edie thinks that Karl is going to pop the question after she finds an engagement ring and prenuptial agreement in his briefcase. Also, Gabrielle and Carlos learn she is highly unable to conceive a child again because of complications caused from her recent miscarriage. Lastly, Bree's problem with alcohol intensifies with the notice of Lynette after Bree babysits her children.

Carlos and Gabrielle decide to adopt, but the process comes to be a lot more difficult than either had expected. Susan finally has her surgery as she finally has medical insurance. Meanwhile, a showdown between Bree and her son Andrew lead to a full out war between mother and son. Also, a dying Noah Taylor learns more about Paul Young and his biological grandson Zach. Lastly, Tom is having more difficulty at the job when having to take orders from his boss and wife Lynette.

Flashbacks take us back to to moving-in day on Wisteria Lane for Bree, Lynette, Susan and Gabrielle and how Mary Alice brought them all together. Back in the present, Bree gets some frightening news. Susan moves into a trailer after her house was burnt down. Lynette and the kids are staying at a hotel. After seeing a report on the news, Gabrielle believes Carlos died. Paul begs Zach to get him a good lawyer via Noah.