Bartlet collapses before his first State of the Union address. Leo publicly admits to his former alcoholism and drug abuse. Things get interesting romantically for both Sam and CJ. Lord John Marbury helps the staff negotiate an agreement between India and Pakistan.

To investigate the cost and availability of AIDS medication needed in Africa, the White House plays host to representatives of American pharmaceutical companies and the president of an African nation; C.J. accidentally leaks information to a freshman reporter; after Sam is shown up by an amateur Republican operative on a television program, Jed decides to hire her.