Josh fails to sway an unruly congressman who insists on voting against the administration on the vice presidential confirmation, but Ryan reaches out to get him to change his mind; Leo fears that the potential defection of a prominent North Korean pianist will jeopardize secret nuclear disarmament talks; Will and Toby are humiliated when an early draft of a speech outlining their struggle to laud Bob Russell's confirmation is erroneously substituted for the final version; Donna's aunt and uncle from Wisconsin pay a visit, testing Josh's ability to refrain from bad cheesehead jokes during their tour of the White House; the staff struggles over how to language the state of the economy; fearing that the administration is drifting off-course, Toby wants to hand over more responsibilities to Will in order to focus on getting back to their core message.

The Bartet clan attempts to gather for a holiday dinner. Jed must deal with a hostage situation in Sudan, an assisted suicide in Oregon, his son-in-law's yearn to run for the House of Representatives, and his grandson's want to spend time with his grandpa. C.J. takes a stand on the assisted suicide because of her father's worsening condition.

President Bartlet attends the funeral of a former president with other former presidents Glenallen Walken and D. Wire Newman, while monitoring a possible situation in Saudi Arabia. Josh Lyman mediates an argument between a representative from Connecticut and one from North Carolina who wants her state's copy of the Bill of Rights returned. CJ is concerned about a scientist's invention which could interfere with privacy.

When five navy E-2C Hawkeye crew members are stranded in North Korea, Bartlet orders a risky Navy Seal rescue attempt. C.J. agrees to one on one with a motormouth conservative talk show host

Donna Moss, Percy Fitzwallace, Andrea Wyatt and a couple of congressmen are in the Middle East on a fact finding mission when their cars are blown up. President Bartlet considers possible military targets to bomb in retaliation. In flashbacks, we see Donna becoming attracted to British photojournalist Colin Ayres.

Jed weighs his options for responding to the bombing as Israeli and Palestinian forces face off against each other; Josh has an interesting reaction when Colin arrives at the hospital to visit Donna; Kate and Leo clash over the advice she's giving Jed; Josh assumes a diplomatic role when the Palestinians approach him to initiate settlement discussions; Toby and Charlie prepare a reluctant Jed for throwing out the first ball at Camden Yards; Donna's life is threatened when she develops a pulmonary embolism; Jed reflects on the days prior to his first inauguration.

Penn and Teller roll a lesson about the First Amendment into their entertainment at Zoey's White House birthday party, setting off a media frenzy and public relations nightmare; Baker drops out of the race, leaving the field free for Russell, who asks Josh to run his campaign; Jed takes a hard line on making significant gains on substantive issues in his last China summit; Vinick turns down Jed's offer of the U.N. ambassadorship to run for president; a fully ambulatory Donna has difficulty scheduling a meeting with Josh; Jed has an MS relapse which leaves him partially paralyzed and in a wheelchair.

As acting chief of staff, Josh calls Leo in for backup when the news about Jed's health hits; the staff follows the progress of an asteroid headed for earth; Jed struggles with his relapse as C.J., Kate, and Toby handle the repercussions of his illness on the progress of the China summit; Josh is outraged when Will uses Jed's paralysis as a political opportunity for Russell; Donna resorts to extreme measures when Josh avoids her repeated attempts to sit down for a personal discussion; after receiving some wise advice from Leo about the future, Josh makes a decision about the man he'll support in the upcoming presidential election.

Lou and Santos run into trouble on the road when they try to pick up a family's vote; their child was shot by a Latino police officer. Also, CJ must manage a crisis between China and Kazakhstan.

After the near-nuclear disaster at the power plant the polls show surprising, or maybe not so surprising, results for both candidates. The Vinick camp gears up for backlash while the Santos camp hopes for cause to celebrate. Meanwhile Bartlet is still trying to keep the situation in Central Asia under control. Relationships in the Santos campaign, the Vinick campaign, and the West Wing all undergo changes and Vinick and Bartlet attempt to deal with different versions of the cold.