Senator Vinick, now the Republican Presidential nominee, receives advice from former Bartlet political consultant Bruno Gianelli on how to win all 50 states in the general election, and more specifically in the near term how to present his religious views to the public and pick a running mate. Meanwhile, Bartlet wrestles with getting a minimum wage hike passed by attaching it to a bill necessary to raise the debt ceiling, and with how to unify his party in the face of a three-way race for the Democratic nomination.

Faced with a Democratic party in disarray in the face of the strongest Republican challenger they have ever had, Bartlet asks Leo to take charge of the potentially chaotic Democratic National Convention, while Santos considers a party-unifying vice-presidential offer from front-runner Russell. Meanwhile, the International Space Station is leaking oxygen and a rescue of the three astronauts will be difficult, and Bartlet catches Charlie leaving Zoey's bedroom after a nighttime visit.

It's three weeks into the presidential campaign and Vinick meets with Frost out on the trail. Santos pulls a stunt which leads to higher approval ratings and jolts the Vinick camp. Vinick and Santos try to kick each other politically while they focus on their messages of the week.

All eyes are looking forward to the Leo McGarry/Ray Sullivan Vice Presidential debate. Meawhile, Santos is trying not to catch his children's cold and he visits his home in Texas and continues to campaign. Jorge Santos, the Congressman's brother, may cause some problems at a gathering.

After the near-nuclear disaster at the power plant the polls show surprising, or maybe not so surprising, results for both candidates. The Vinick camp gears up for backlash while the Santos camp hopes for cause to celebrate. Meanwhile Bartlet is still trying to keep the situation in Central Asia under control. Relationships in the Santos campaign, the Vinick campaign, and the West Wing all undergo changes and Vinick and Bartlet attempt to deal with different versions of the cold.