The 15-year old son of an Iranian leader needs a heart transplant in the U.S. Problem is, the only man who could do it is an enemy of the Iranian government; The Senate minority leader threatens to thwart the President's legislative agenda when he believes that Hoynes is doing some political maneuvering for the next Presidential election; Toby offers a Congresswoman a Cabinet position but is forced to take back the offer.

As the search for Zoey continues, Walken takes a hard line against the kidnappers that could contribute to her death; Danny releases the Shareef story, and the revelation creates a rift that separates Jed from Abbey and Liz; tensions arise between Walken's staff and Bartlet's staff; the Democratic leadership in Congress assails Leo for allowing Jed to step aside; in retaliation for Shareef's death, a movie theater in Turkey is bombed, and eighty people, including American soldiers, are killed.

When he realizes that his first choice for Vice President faces an uphill fight for nomination, Jed nominates a congressman that none of the staff can get excited about; Josh is less than thrilled with his new intern.