Футуристический мегаполис Сан-Франсокио. В первый учебный день в вузе юный гений робототехники Хиро Хамада знакомится со строгим новым деканом – профессором Гренвилл. В лаборатории трагически погибшего старшего брата Тадаши Хиро находит старый чип медицинского робота Бэймакса и решает его восстановить. Однако эндоскелет Бэймакса сбегает и оказывается в руках Ямы, и он обещает Хиро вернуть скелет, если тот выкрадет пресс-папье со стола декана. Яма обманывает Хиро, но его друзья-супергерои – Фред, ГоГо, Хани и Васаби – выручают паренька. Бэймакс вернулся! Хэппи-энд? Не совсем…

Яма создал по образцу эндоскелета Бэймакса целую банду боевых роботов, которые терроризируют город. Но это только отвлекающий маневр, чтобы похитить пресс-папье профессора Гренвилл, которое, оказывается, можно использовать в злодейских целях. Друзьям Хиро и верному Бэймаксу приходится вновь объединиться в команду, чтобы предотвратить надвигающуюся катастрофу. Шестерка героев снова в сборе, они не планировали становиться супергероями, но жизнь не всегда идет по плану. А теперь им придется приложить все свои знания и умения, чтобы жители Сан-Франсокио могли спокойно жить.

As Hiro tries to find a way to connect to classmate Karmi, Go Go and Fred dive deep into comic book mythology to defeat High Voltage, a mother-daughter supervillain duo.

Go Go and Honey Lemon quickly clash when they become roommates. Meanwhile, when a thief steals Honey Lemon’s chem-lab purse, it accidentally turns him into a monster.

When supervillain Baron Von Steamer crashes Fred’s Bro-Tillion, the Big Hero 6 team springs into action.

When Aunt Cass stumbles into an underground cooking competition, she thrives and becomes addicted to the excitement.

Hiro, Fred, and Baymax follow GoGo into the mysterious Muirahara Woods where they get lost and everything electronic strangely fails including Baymax.

Hiro becomes demoralized when his latest school project fails spectacularly; the team must take on the incompetent villain, Globby.

After Aunt Cass nearly discovers Hiro's secret membership in the Big Hero 6, Hiro tries to set her up with someone to distract her.

Although he is obviously ill, Hiro refuses to listen to his team-mates and Baymax and only watch from afar as they fight the mercenary team Mad Jacks.

Crazy game show host Mr. Sparkles threatens to hurt Hiro's cat Mochi to force Go Go to join a game. But she is very afraid of public appearances.

Wasabi's need for order clashes with Hiro's chaotic work style when they collaborate on a school project.

Hiro becomes frustrated when he's deemed too young to attend a science workshop hosted by SFIT's most famous alumni, Dr. Trevor Trengrove.

Hiro decides to upgrade himself with super strength.

Honey Lemon takes art classes at a rival school.

Karmi posts Big Hero 6 fan fiction, embarrassing Hiro.

Hiro invents a tiny robot, Mini-Max, to supervise and be a sidekick to Fred while the rest of the team is in class.

Richardson Mole blackmails his way into Big Hero 6.

When a monster wreaks havoc in San Fransokyo, Big Hero 6 must go on a real-life monster hunt.

Hiro and the others plan the ultimate birthday surprise for Wasabi by recovering his car from the bottom of the bay, but Baron Von Steamer ruins the celebration.

To try to prove Yama is behind a mysterious crime spree, perpetrated by tiny bots, Hiro is drawn back into the illegal world of bot-fighting.

After the gang goes to a spooky haunted house, Hiro keeps seeing Tadashi around the city and ultimately finds himself face to face with his brother.

Big Hero 6 face their greatest challenge as Obake unleashes his plan on San Fransokyo.