In California's Simi Valley, 20-year-old Megan Barroso is heading home from a July 4th party when she disappears. Her car is found stranded on Highway 23 - riddled by bullets from an AK47. Chris unfolds the harrowing tale of a truly evil predator.

Anthony Lee used to be a well-known drag queen in Tampa's nightclubs. But while cooking dinner at his friend Tiffany's house, he's gunned down by an angry intruder as Tiffany hides in the bathroom. The motive will lead Chris to uncover his killer.

In Gulf Harbors, Florida, retiree Jean Schwarzkopf is a woman of means who enjoys the company of younger men. When she is found murdered in her own home, there are several suspects. Chris Hansen finds the motive is what gives the killer away.

In Topeka, KS, Mike Sisco and Karen Harkness have invited their parents over to celebrate their upcoming wedding. Instead, the couple is found gunned down in their own bed. Whoever did it left no trace. Chris goes after the motive to the mystery.

Yale University medical researcher Annie Le is about to get married, but she vanishes on her way to her lab. The frantic search for her turns into a nation-wide sensation. Now, for the first time on TV, Chris reveals what really happened to her.

In Canyon, TX, teenager Fred Moseley is left home alone over a long weekend – and abruptly disappears. His beloved new car is found abandoned on the outskirts of town… his shotgun missing. Chris Hansen investigates a mystery that lasted ten years.

In St. Augustine, FL, Jesse Whitley is a small-time scoundrel who drives off on a stormy night, never to return. His body is found floating in the St. John’s river, and police have a list of suspects. It takes 17 years to bring his killer to justice.

Although Josh Bailey suffers from mental disabilities, he’s managed to carve out a decent life for himself. But after he disappears, his parents fear he’s fallen in with the wrong crowd. Chris travels to Chapel Hill, NC to uncover the true story.

Jim Madonna doesn’t have much to be grateful for on Thanksgiving. He recently lost his job. But when his son finds him shot to death, killed in his own car, all of Taunton, MA is shocked. Chris reveals a grim holiday tale of murder and betrayal.