Tig Notaro, an LA-based radio host, returns to her hometown of Bay St. Lucille, Mississippi, to be at the bedside of her ailing mother, Caroline. Suffering from her own recent health problems, Tig attempts to reconnect with her brother, Remy, and stepfather, Bill, both of whom lack the emotional tools to deal with family trauma.

Struggling to accept her mother's death, Tig can't let go of Caroline's possessions. Unable to leave home, Tig tries to maintain control of her radio show from Mississippi. Seeing that Tig is unable to accept the fragility of life, most pressingly her own, Bill pushes her to investigate a disturbing, yet oddly hilarious medical procedure.

Bill's cat escapes and he blames Tig for letting her out. Tig's biological father, Mick, leads a search party. Assigned to survey the neighborhood, Tig unearths a secret from Caroline's past. Having found a local station where she can record her show remotely, Tig connects with Kate, the off-beat radio station manager.

Finally feeling better, Tig readies for her return to LA. But before she goes, she is roped into replacing her mother as Mardi Gras Queen at the Bay St. Lucille parade. Remy and Bill are stymied in their search for romance and cats, respectively. Tig searches for Kate at the parade, but instead encounters Jessie, a news reporter who makes her want to stay in town a bit longer.

Tig and Jessie explore the limits of living in the moment. Attempting to connect, Bill attempts to organize a family dinner with Tig and Remy. Remy clumsily pursues a female member of his Civil War reenactment club. Tig and Bill finally have it out over painful events of the past.

Tig returns to Los Angeles and discovers that life has moved on without her. Encounters with friends, an ex-girlfriend, and coworkers all lead her to a crossroads, where a life-altering decision must be made.

Hoping to get more intimate with Kate, Tig attends a party at her apartment in New Orleans. Later, Tig and Kate stoke controversy in Bay St Lucille with a discussion on their radio show. Bill is oblivious to the attentions of an admirer, while Remy blows it with a lady friend when a joke leads to a political disagreement.

Tig goes on a complicated date. Bill makes a connection with a woman in his office building. Remy also meets someone, at church. A mysterious crystal brings the family together.

Tig and Kate deal with negative reactions to their radio show, leading them to a career opportunity. Remy and Bill attend an emotionally charged party at the senior center, while Tig and Kate go fishing and their relationship deepens.

Kate pulls back but might be jealous of Tig's chemistry with a sexy musician. Bill and Remy separately attempt to rise to challenges presented by dating Felicia and Desiree.

Frustrated by the impossibility of a relationship with Kate, Tig withdraws. Kate has a disturbing encounter at work which infuriates Tig. Remy hosts a dinner at Bill's house with an unexpectedly long guest list.

Thwarted in their attempt to deal with their uncomfortable work situation, Tig takes their situation to the airwaves and tells a powerful personal story. Bill attends a wedding with Felicia and makes an impression on her family. Tig supports Bill and Remy, as the men face difficult truths. Tig and Kate go to a new place in their relationship.