Zack, the new kid in town, finds that even a simple trip to school becomes an adventure when he meets Milo Murphy.

After science teacher Mrs. Murawski announces a science project, Milo, Zack, and Melissa must overcome Murphy's Law to protect an egg and their grades.

Milo, Cavendish, and Dakota travel back to 1965 and inspire the creation of Dr. Zone only to encounter a sinister plot to take over the world.

Milo, Zack, and Melissa—with help from Phineas, Ferb, Candace, Buford, and Baljeet—help conquer Murphy's law to stop a swarm of Pistachions.

Milo faces down a cosmic storm made of negative probability ions, while Melissa, Zack, Cavendish, Dakota, Perry, and Doof work their way through the alien populace to save their friend.