Using only a wrench and rope, MacGyver must diffuse a bomb set near the United Nations by his old nemesis, “The Ghost”, a notorious criminal whose work killed his mentor, and track him down before he strikes again.

When Mac and Jack are trapped inside Mac's house, which his nemesis, The Ghost, has rigged with explosives, Mac uses a karaoke mic and an audio transformer to let the team know that this bomb is a distraction for a bigger one. Also, through flashbacks, Mac and Jack's contentious first meeting unfolds.

MacGyver and the team set off on a dangerous capture operation after an Irish military intelligence officer approaches them claiming to know the whereabouts of “The Ghost,” a lethal bomb maker whom Mac has been hunting for years.

MacGyver faces off with a cunning new adversary whose carefully crafted plans put Mac at the epicenter of an impossible choice: save the life of a friend, or save the lives of hundreds of innocents. Also, Mac receives new information that will drive a wedge between him and his father.