When MacGyver comes face to face with Murdoc, an international assassin hired to kill him, Mac must defend both himself and Bozer, armed with only a corkscrew and paper towel rolls. Also, Bozer feels completely betrayed when he finally learns Mac's true identity.

MacGyver and Jack search for Riley, using a microwave and a power strip, after she mysteriously disappears and hacks into the NSA, possibly unleashing World War III. Also, Bozer goes on his first official mission, and Jack opens up about his history with Riley’s mother, Diane.

When Mac and the team travel to Hawaii to aid in earthquake relief efforts, they team up with Chin and Kono from the Five-0 task force to rescue a group of government scientists trapped in a building. However, as they work on the complicated rescue, a group using the chaos as a distraction aims to steal the top-secret weaponry from the scientists.

The team is pulled away from their Halloween plans when they head into the dreaded Bermuda Triangle to retrieve the Vice President’s son after his plane goes down with a mysterious prisoner on board.

When MacGyver and Jack "steal" a priceless painting, using a table cloth and a shoe lace, in order to draw an infamous stolen art dealer out of hiding, they wind up getting conned out of the painting by the dealer's team. Also, Riley's estranged father, Elwood, asks to be part of her life, and Matty sends Bozer to a spy training camp.

When Matty and the team search for a former government tech who stole classified intel and has been evading capture, they reunite with the Coltons, the family of bounty hunters, who are pursuing the same man for different reasons.

When a vial containing a deadly virus is stolen from the Center for Disease Control in Atlanta, MacGvyer and team race to recover it before the thief unleashes a global pandemic.

MacGyver and team are asked to solve a locked-door mystery when a man working inside a remote, ultra-secure international seed vault disappears.

Matty’s ex-husband, Ethan, asks her for help when a criminal organization, S-Company, kidnaps his wife and daughter, forcing Matty to decide if she’s willing to commit treason in order to help him save his family. Also, Riley joins Billy Colton and Mama Colton on a mission to Paris and makes a heartbreaking discovery.