It’s been ten weeks since his wife, Alex, was killed in a car accident; and President Kirkman’s senior staff insist he seek professional help in dealing with his loss, forcing him to reluctantly see therapist Dr. Adam Louden. Meanwhile, FBI Agent Hannah Wells and Aaron Shore travel to Cuba as part of a trade delegation, but the trip does not go according to plan. With lives in the balance, Kirkman is challenged with a decision that will test his role as commander in chief during this time of personal tragedy.

White House Council Kendra Daynes finds herself in a dangerous situation that puts another White House staffer's life at risk, while Hannah Wells takes an unexpected trip for answers.

A political attack on Kirkman puts privacy and transgender rights in the spotlight. Aaron weighs a major decision. Wells and Eli track a bioterrorist.