Business becomes personal for Bull when TAC assists with a civil suit against the bank that funded the terrorists responsible for Cable's death. Also, Marissa enlists her former homeland security co-worker and international banking cyber-investigator, Taylor Rentzel, to help with the suit.

Bull takes on the trial defense of Dr. Natalie Reznick, an expert on anthrax, who is accused of orchestrating a series of anthrax attacks that terrorize the city. While the facts are against her, Bull sets out to prove the city was in such a rush to get the bacteria off the streets and calm the public's hysteria, they arrested the wrong person.