Bull’s efforts to assist with his ex-wife Isabella Colón’s defense in a wrongful death lawsuit are hindered by unresolved issues from their marriage and her longstanding rift with her brother, Benny.

The DA's office asks Bull to assist them in their prosecution of a fraternity when a pledge accidentally drowns during a hazing incident, but his efforts may be derailed when the students close ranks to stonewall him.

Bull travels to a small town on a personal mission to help his high school sweetheart sue a local factory that she believes is making residents ill by contaminating the water.

Bull and his on-again, off-again romantic rival, Diana Lindsay, join forces to create two separate but collaborative defense teams when Diana's niece and her husband are charged with armed robbery. As the trial gets underway, Bull's reunion with Diana is strained by his new post-heart attack regimen.

Bull’s new relationship with Diana, his on-again romantic rival, is complicated by his renewed feelings for his ex-wife, Isabella, when they’re reunited by the sudden death of her and Benny’s father. Also, a deceased tech billionaire’s brother comes to TAC for help in bringing suit against the doctor he holds personally responsible for the tycoon’s death.

Bull helps a famous social media influencer, Sadie Washington, take her father to court to overturn his legal guardianship over her empire, which he was granted after the young mogul suffered a public mental breakdown. To counteract any jury bias Sadie faces due to the public’s perception of her mental illness, they aim to select jurors who believe in giving people second chances.

TAC braces for an un-jolly Christmas when Bull and Benny represent Marissa and her estranged husband, Greg, in federal court after they're charged with money laundering and fraud connected to Greg's restaurant. As Bull and Benny defend the divorcing couple together so the prosecution can't use them against each other, they search for jurors who will believe Marissa had no knowledge of Greg's business dealings. Also, as Bull and Izzy prepare to baptize Astrid before the Christmas holiday, they reach an impasse regarding what they want from their renewed relationship.

Bull faces uncertainty in court, when TAC handles a class action suit against a vaping company selling malfunctioning devices, and the trial outcome hinges on just one juror. Marissa takes the initiative when Bull ignores TAC’s growing financial difficulties.