Bull impulsively agrees to have Benny represent Adam Harris, a young man charged with murder for helping his terminally ill girlfriend end her life, a decision which clashes with Benny’s religious beliefs.

Bull and his on-again, off-again romantic rival, Diana Lindsay, join forces to create two separate but collaborative defense teams when Diana's niece and her husband are charged with armed robbery. As the trial gets underway, Bull's reunion with Diana is strained by his new post-heart attack regimen.

Bull and the TAC team question whether they have a solid defense when they represent wealth manager Rachel Elliot who’s on trial for her husband’s murder, which she claims to have no memory of due to an alcohol-induced blackout. When Rachel’s reputation for aggressive behavior threatens to hurt them in court, Bull avoids jurors with “rage bias,” an inherent dislike of people who can’t control their emotions.

Izzy asks Bull to petition the court to have her best friend’s body exhumed when the woman’s son alleges she was murdered, despite her death already ruled accidental.