Bull confronts his guilt over closing his psychiatric practice to start TAC when his former patient, a young woman who is a clinical sociopath, goes on trial for killing her brother. When Bull and Benny’s client has no memory of the crime due to her mental condition, they enter a "Not Guilty by Reason of Insanity" plea and aim to seat jurors that are sympathetic to mental illness.

Bull helps a famous social media influencer, Sadie Washington, take her father to court to overturn his legal guardianship over her empire, which he was granted after the young mogul suffered a public mental breakdown. To counteract any jury bias Sadie faces due to the public’s perception of her mental illness, they aim to select jurors who believe in giving people second chances.

Bull and Chunk represent an emergency room doctor being sued for malpractice after she ignored direct orders to save one near-death patient in favor of helping another who was also critically injured.