Bull returns to work following his heart attack with a new rich client for the firm to represent: an insurance company being sued by a dying mother for denying coverage of her liver transplant.

Bull finds himself serving jury duty while simultaneously mounting a defense for a woman on trial for killing her daughter's murderer.

Business becomes personal for Bull when TAC assists with a civil suit against the bank that funded the terrorists responsible for Cable's death. Also, Marissa enlists her former homeland security co-worker and international banking cyber-investigator, Taylor Rentzel, to help with the suit.

Bull confronts his guilt over closing his psychiatric practice to start TAC when his former patient, a young woman who is a clinical sociopath, goes on trial for killing her brother. When Bull and Benny’s client has no memory of the crime due to her mental condition, they enter a "Not Guilty by Reason of Insanity" plea and aim to seat jurors that are sympathetic to mental illness.

Bull takes on a pro bono client who was poorly advised by his public defender to plead guilty to a misdemeanor assault charge and is now facing felony manslaughter after the victim dies.

Danny enlists her colleagues to help when her boyfriend, Gabriel, is arrested for being in the country illegally and threatened with deportation. Also, Bull represents a German national who is being sued by a museum over possession of a valuable painting.